Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96623 | Target Info | |||
| Target Name | Heat shock protein 90 beta (HSP90B) | ||||
| Synonyms |
Heat shock 84 kDa; HSP84; HSP 84
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| Target Type | Clinical trial Target | ||||
| Gene Name | HSP90AB1 | ||||
| Biochemical Class | Heat shock protein | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Heat shock protein 90 alpha (HSP90A) | Successful Target | ||||
| UniProt ID | HS90A_HUMAN | |||||
| Gene Name | HSP90AA1 | |||||
| Synonyms |
Renal carcinoma antigen NY-REN-38; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; LAP-2; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSPCA; HSPC1; HSP90A; HSP86; HSP 86
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| Representative Drug(s) | TAS-116 | Drug Info | Ki = 34.7 nM | Click to Show More | [1] | |
| 2 | SNX-5422 | Drug Info | IC50 = 38 nM | [2] | ||
| 3 | PU-H71 | Drug Info | IC50 = 43 nM | [3] | ||
| Co-Target Name | Endoplasmin (HSP90B1) | Clinical trial Target | ||||
| UniProt ID | ENPL_HUMAN | |||||
| Gene Name | HSP90B1 | |||||
| Synonyms |
gp96 homolog; Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP94; GRP-94; 94 kDa glucoseregulated protein; 94 kDa glucose-regulated protein
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| Representative Drug(s) | PU-H71 | Drug Info | IC50 = 26 nM | [4] | ||
| Co-Target Name | Heat shock protein 75 kDa mitochondrial (TRAP1) | Co-Target | ||||
| UniProt ID | TRAP1_HUMAN | |||||
| Gene Name | TRAP1 | |||||
| Synonyms |
Heat shock protein 75 kDa, mitochondrial; HSP 75; TNFR-associated protein 1; Tumor necrosis factor type 1 receptor-associated protein; TRAP-1
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| Representative Drug(s) | PU-H71 | Drug Info | IC50 = 205 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions. J Med Chem. 2020 Mar 12;63(5):1798-1822. | ||||
| REF 2 | Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation. J Med Chem. 2020 May 28;63(10):5421-5441. | ||||
| REF 3 | Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J Med Chem. 2013 Sep 12;56(17):6803-18. | ||||
| REF 4 | Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015 May 14;58(9):3922-43. | ||||
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