Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F3NF
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| Drug Name |
TAS-116
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| Synonyms |
Tas-116; 1260533-36-5; UNII-PLO044MUDZ; PLO044MUDZ; SCHEMBL2694525; CHEMBL3661115; BDBM126083; ZINC169703510; KB-334563; US8779142, 102; Benzamide, 3-ethyl-4-(3-(1-methylethyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo(3,4-b)pyridin-1-yl)-; 3-ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzamide; 3-Ethyl-4-(3-(1-methylethyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo(3,4-b)pyridin-1-yl)benzamide
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Taiho Oncology Princeton, NJ
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H26N8O
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| Canonical SMILES |
CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C
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| InChI |
1S/C25H26N8O/c1-5-16-10-17(24(26)34)6-7-20(16)33-25-22(23(30-33)15(2)3)21(8-9-27-25)32-13-19(28-14-32)18-11-29-31(4)12-18/h6-15H,5H2,1-4H3,(H2,26,34)
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| InChIKey |
NVVPMZUGELHVMH-UHFFFAOYSA-N
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| CAS Number |
CAS 1260533-36-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Heat shock protein 90 beta (HSP90B) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| PI3K-Akt signaling pathway | ||||
| Necroptosis | ||||
| Antigen processing and presentation | ||||
| NOD-like receptor signaling pathway | ||||
| IL-17 signaling pathway | ||||
| Th17 cell differentiation | ||||
| Progesterone-mediated oocyte maturation | ||||
| Estrogen signaling pathway | ||||
| Pathways in cancer | ||||
| Prostate cancer | ||||
| Fluid shear stress and atherosclerosis | ||||
| References | Top | |||
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| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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