Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94085 | Target Info | |||
| Target Name | Retinoic acid receptor alpha (RARA) | ||||
| Synonyms |
RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
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| Target Type | Clinical trial Target | ||||
| Gene Name | RARA | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Retinoic acid receptor beta (RARB) | Successful Target | ||||
| UniProt ID | RARB_HUMAN | |||||
| Gene Name | RARB | |||||
| Synonyms |
RAR-epsilon; RAR-beta; Nuclear receptor subfamily 1 group B member 2; NR1B2; HBV-activated protein; HAP
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| Representative Drug(s) | Tamibarotene | Drug Info | Ki = 30 nM | [1] | ||
| Co-Target Name | Retinoic acid receptor gamma (RARG) | Successful Target | ||||
| UniProt ID | RARG_HUMAN | |||||
| Gene Name | RARG | |||||
| Synonyms |
RAR-gamma; Nuclear receptor subfamily 1 group B member 3; NR1B3
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| Representative Drug(s) | Tamibarotene | Drug Info | EC50 = 591 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J Med Chem. 1997 Dec 19;40(26):4222-34. | ||||
| REF 2 | Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. J Med Chem. 2010 Oct 14;53(19):6779-810. | ||||
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