Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02GTY
|
|||
| Former ID |
DIB013793
|
|||
| Drug Name |
Tamibarotene
|
|||
| Synonyms |
Tamibarotene (oral, Alzheimer's disease)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | T-cell leukaemia [ICD-11: 2A90; ICD-10: C86] | Phase 3 | [1] | |
| Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 2/3 | [2], [3] | ||
| Company |
Research Foundation Itsuu Laboratory
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C22H25NO3
|
|||
| Canonical SMILES |
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C
|
|||
| InChI |
1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
|
|||
| InChIKey |
MUTNCGKQJGXKEM-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 94497-51-5
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:32181
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor alpha (RARA) | Target Info | Modulator | [4], [5] |
| Retinoic acid receptor beta (RARB) | Target Info | Modulator | [4], [5] | |
| KEGG Pathway | Pathways in cancer | |||
| Small cell lung cancer | ||||
| Non-small cell lung cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Acute myeloid leukemia | ||||
| Pathway Interaction Database | Retinoic acid receptors-mediated signaling | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Mesodermal Commitment Pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Nuclear Receptors | ||||
| Adipogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04797780) SY-1425 Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome. U.S. National Institutes of Health. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648). | |||
| REF 3 | Tamibarotene. Drugs Today (Barc). 2007 Aug;43(8):563-8. | |||
| REF 4 | Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12. | |||
| REF 5 | A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver.Obesity (Silver Spring).2013 Jan;21(1):E22-5. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.