Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91480 | Target Info | |||
| Target Name | ATP-binding cassette transporter C8 (ABCC8) | ||||
| Synonyms |
Sulfonylurea receptor 1; SUR1-type K(ATP) channel; SUR1; Kir6.2/SUR1; ATPbinding cassette subfamily C member 8; ABCC8
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| Target Type | Successful Target | ||||
| Gene Name | ABCC8 | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | ||||
| UniProt ID | PPARG_HUMAN | |||||
| Gene Name | PPARG | |||||
| Synonyms |
PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
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| Representative Drug(s) | Glibenclamide | Drug Info | Ki = 660 nM | [1] | ||
| Co-Target Name | Bacterial Beta-lactamase AmpC (Bact ampC) | Co-Target | ||||
| UniProt ID | AMPC_ECOLI | |||||
| Gene Name | Bact ampC | |||||
| Synonyms |
Bacterial Cephalosporinase
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| Representative Drug(s) | Glibenclamide | Drug Info | IC50 = 5 . | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis. J Nat Prod. 2019 Feb 22;82(2):259-264. | ||||
| REF 2 | Identification and prediction of promiscuous aggregating inhibitors among known drugs. J Med Chem. 2003 Oct 9;46(21):4477-86. | ||||
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