Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T87374 Target Info
Target Name COVID-19 spike glycoprotein (S)
Synonyms
COVID-19 S glycoprotein; COVID-19 E2; COVID-19 Peplomer protein
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Gene Name COVID-19 S
Biochemical Class Betacoronaviruses spike protein family
UniProt ID
SPIKE_SARS2
Co-Targets of This Target  Top
Co-Target Name Cationic trypsinogen (PRSS1) Successful Target
UniProt ID TRY1_HUMAN
Gene Name PRSS1
Synonyms
Trypsin-1; Trypsin I; TRYP1; TRY1; TRP1; Serine protease 1; Beta-trypsin
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Representative Drug(s) Nafamostat Drug Info IC50 = 17 nM [1]
Co-Target Name Complement C1s component (C1S) Successful Target
UniProt ID C1S_HUMAN
Gene Name C1S
Synonyms
Complement component 1 subcomponent s; Complement C1s subcomponent; C1-esterase; C1 esterase
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Representative Drug(s) Nafamostat Drug Info IC50 = 29 nM [2]
Co-Target Name Plasminogen (PLG) Successful Target
UniProt ID PLMN_HUMAN
Gene Name PLG
Synonyms
Plasmin
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Representative Drug(s) Nafamostat Drug Info IC50 = 240 nM [3]
Co-Target Name Coagulation factor IIa (F2) Successful Target
UniProt ID THRB_HUMAN
Gene Name F2
Synonyms
Prothrombin; Coagulation factor II
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Representative Drug(s) Nafamostat Drug Info IC50 = 290 nM [3]
Co-Target Name Suppressor of tumorigenicity 14 protein (ST14) Patented-recorded Target
UniProt ID ST14_HUMAN
Gene Name ST14
Synonyms
Tumor-associated differentially-expressed gene 15 protein; Tumor associated differentially-expressed gene-15 protein; TADG15; Serine protease TADG-15; Serine protease 14; SNC19; Prostamin; PRSS14; Membrane-type serine protease 1; Membrane type serine protease 1; Matriptase; MT-SP1
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Representative Drug(s) Nafamostat Drug Info Ki = 0.02 nM [4]
Co-Target Name Serine protease hepsin (HPN) Patented-recorded Target
UniProt ID HEPS_HUMAN
Gene Name HPN
Synonyms
Transmembrane protease, serine 1; HPN; HEPSIN
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Representative Drug(s) Nafamostat Drug Info Ki = 0.53 nM [4]
Co-Target Name Hepatocyte growth factor activator (HGFAC) Literature-reported Target
UniProt ID HGFA_HUMAN
Gene Name HGFAC
Synonyms
Hepatocyte growth factor activator long chain; HGFAC; HGFA; HGF activator
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Representative Drug(s) Nafamostat Drug Info Ki = 25 nM [5]
Co-Target Name Tissue kallikrein (KLK1) Literature-reported Target
UniProt ID KLK1_HUMAN
Gene Name KLK1
Synonyms
Kidney/pancreas/salivary gland kallikrein; Kallikrein1; Kallikrein-1
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Representative Drug(s) Nafamostat Drug Info IC50 = 650 nM [3]
Co-Target Name Complement C1r (C1R) Co-Target
UniProt ID C1R_HUMAN
Gene Name C1R
Synonyms
Complement C1r subcomponent; Complement component 1 subcomponent r
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Representative Drug(s) Nafamostat Drug Info IC50 = 800 nM [2]
References  Top
REF 1 Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease. Bioorg Med Chem Lett. 1999 Mar 22;9(6):815-20.
REF 2 Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem. 2018 Apr 26;61(8):3253-3276.
REF 3 Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors. Bioorg Med Chem Lett. 1996 Mar 19;6(6):679-82.
REF 4 Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15;23(10):2328-43.
REF 5 Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer. ACS Med Chem Lett. 2014 Oct 9;5(11):1219-24.

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