Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86437 | Target Info | |||
| Target Name | HUMAN janus kinase 1 (JAK-1) | ||||
| Synonyms |
Tyrosine-protein kinase JAK1; JAK1B; JAK1A
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| Gene Name | JAK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Janus kinase 2 (JAK-2) | Successful Target | ||||
| UniProt ID | JAK2_HUMAN | |||||
| Gene Name | JAK2 | |||||
| Synonyms |
Tyrosine-protein kinase JAK2
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| Representative Drug(s) | Ruxolitinib | Drug Info | IC50 = 0.056 nM | [1] | ||
| Co-Target Name | Janus kinase 3 (JAK-3) | Successful Target | ||||
| UniProt ID | JAK3_HUMAN | |||||
| Gene Name | JAK3 | |||||
| Synonyms |
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
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| Representative Drug(s) | Ruxolitinib | Drug Info | IC50 = 2.8 nM | [2] | ||
| Co-Target Name | TYK2 tyrosine kinase (TYK2) | Successful Target | ||||
| UniProt ID | TYK2_HUMAN | |||||
| Gene Name | TYK2 | |||||
| Synonyms |
Non-receptor tyrosine-protein kinase TYK2
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| Representative Drug(s) | Ruxolitinib | Drug Info | IC50 = 0.4 nM | [3] | ||
| Co-Target Name | Histone deacetylase 6 (HDAC6) | Clinical trial Target | ||||
| UniProt ID | HDAC6_HUMAN | |||||
| Gene Name | HDAC6 | |||||
| Synonyms |
KIAA0901; JM21; HD6
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| Representative Drug(s) | Ruxolitinib | Drug Info | IC50 = 15 nM | [4] | ||
| Co-Target Name | Tyrosine protein kinase JAK2-Non receptor tyrosine protein kinase TYK2 complex (JAK2-TYK2) | Co-Target | ||||
| UniProt ID | JAK2_HUMAN-TYK2_HUMAN | |||||
| Gene Name | JAK2-TYK2 | |||||
| Representative Drug(s) | Ruxolitinib | Drug Info | IC50 = 818 nM | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat. J Med Chem. 2017 Oct 26;60(20):8336-57. | ||||
| REF 2 | Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1803-8. | ||||
| REF 3 | Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1116-21. | ||||
| REF 4 | Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923. | ||||
| REF 5 | Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases. J Med Chem. 2014 Jun 26;57(12):5023-38. | ||||
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