Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T79591 Target Info
Target Name Thyroid hormone receptor alpha (THRA)
Synonyms
V-erbA-related protein 7; THRA2; THRA1; Nuclear receptor subfamily 1 group A member 1; NR1A1; ERBA1; EAR7; EAR-7; C-erbA-alpha; C-erbA-1
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Target Type Successful Target
Gene Name THRA
Biochemical Class Nuclear hormone receptor
UniProt ID
THA_HUMAN
Co-Targets of This Target  Top
Co-Target Name Thyroid hormone receptor beta (THRB) Successful Target
UniProt ID THB_HUMAN
Gene Name THRB
Synonyms
c-erbA-beta; c-erbA-2; THR1; Nuclear receptor subfamily 1 group A member 2; NR1A2; ERBA2
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Representative Drug(s) tiratricol Drug Info IC50 = 0.04074 nM Click to Show More [1]
2 Liothyronine Drug Info Ki = 0.08 nM [2]
References  Top
REF 1 2D QSAR studies on thyroid hormone receptor ligands. Bioorg Med Chem. 2007 Jul 1;15(13):4609-17.
REF 2 Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett. 2003 Feb 10;13(3):379-82.

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