Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72171 | Target Info | |||
| Target Name | CCR5 messenger RNA (CCR5 mRNA) | ||||
| Synonyms |
HIV-1 fusion coreceptor (mRNA); HIV-1 fusion co-receptor (mRNA); Chemokine receptor CCR5 (mRNA); CMKBR5 (mRNA); CHEMR13 (mRNA); CD195 antigen (mRNA); CD195 (mRNA); CCR-5 (mRNA); CC-CKR-5 (mRNA); C-C chemokine receptor type 5 (mRNA); C-C CKR-5 (mRNA)
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| Target Type | Successful Target | ||||
| Gene Name | CCR5 | ||||
| Biochemical Class | mRNA target | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | C-X-C chemokine receptor type 5 (CXCR5) | Clinical trial Target | ||||
| UniProt ID | CXCR5_HUMAN | |||||
| Gene Name | CXCR5 | |||||
| Synonyms |
Monocyte-derived receptor15; Monocyte-derived receptor 15; MDR15; MDR-15; Chemokine receptor CXCR5; CXCR-5; CXC-R5; CD185; Burkitt'S lymphoma receptor 1; Burkitt lymphoma receptor 1; BLR1
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| Representative Drug(s) | Maraviroc | Drug Info | IC50 = 0.0024 ug.mL-1 | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship. J Med Chem. 2012 Dec 13;55(23):10405-13. | ||||
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