Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T69685 Target Info
Target Name Glycine transporter GlyT-1 (SLC6A9)
Synonyms
Solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1; Glycine type-1 transporter; Glycine transporter type 1; GlyT1; GlyT-1
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Target Type Clinical trial Target
Gene Name SLC6A9
Biochemical Class Neurotransmitter:sodium symporter
UniProt ID
SC6A9_HUMAN
Co-Targets of This Target  Top
Co-Target Name Liver carboxylesterase (CES1) Successful Target
UniProt ID EST1_HUMAN
Gene Name CES1
Synonyms
Serine esterase 1; Monocyte/macrophage serine esterase; Human carboxylesterase 1; HMSE; HCE1; CES1; Brain carboxylesterase hBr1; Acyl coenzyme A:cholesterol acyltransferase
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Representative Drug(s) R1678 Drug Info Ki = 2.1 nM [1]
Co-Target Name Carboxylesterase 2 (CES2) Co-Target
UniProt ID EST2_HUMAN
Gene Name CES2
Synonyms
Cocaine esterase; CE-2; hCE-2; Methylumbelliferyl-acetate deacetylase 2
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Representative Drug(s) R1678 Drug Info Ki = 5.6 nM [1]
References  Top
REF 1 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.

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