Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B6IZ
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| Former ID |
DCL000604
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| Drug Name |
R1678
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| Synonyms |
R-1678; RG-1678
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Phase 3 | [1], [2] | |
| Company |
Roche
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H14O4
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| Canonical SMILES |
C1=CC=C(C=C1)C(=O)C(=O)C2=CC=C(C=C2)C(=O)C(=O)C3=CC=CC=C3
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| InChI |
1S/C22H14O4/c23-19(15-7-3-1-4-8-15)21(25)17-11-13-18(14-12-17)22(26)20(24)16-9-5-2-6-10-16/h1-14H
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| InChIKey |
FUEGWHHUYNHBNI-UHFFFAOYSA-N
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| CAS Number |
CAS 3363-97-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine transporter GlyT-1 (SLC6A9) | Target Info | Blocker | [3] |
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | NRF2 pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7546). | |||
| REF 2 | ClinicalTrials.gov (NCT01235559) A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25305). U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of Roche (2009). | |||
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