Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T65200 Target Info
Target Name Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Synonyms
HSD11B1; 11beta-HSD1A; 11HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-HSD1; 11-DH; 11 beta-hydroxysteroid dehydrogenase type 1
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name HSD11B1
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
DHI1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) Clinical trial Target
UniProt ID DHI2_HUMAN
Gene Name HSD11B2
Synonyms
NAD-dependent 11-beta-hydroxysteroid dehydrogenase; HSD11B2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; 11-DH2; 11 beta-hydroxysteroid dehydrogenase type 2; 11 beta-HSD2
    Click to Show/Hide
Representative Drug(s) GLYCYRRHIZIN Drug Info IC50 = 0.4 nM [1]
Co-Target Name Estradiol 17-beta-dehydrogenase 2 (HSD17B2) Co-Target
UniProt ID DHB2_HUMAN
Gene Name HSD17B2
Synonyms
17-beta-hydroxysteroid dehydrogenase type 2; 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogenase
    Click to Show/Hide
Representative Drug(s) BVT.2733 Drug Info IC50 = 96 nM [2]
References  Top
REF 1 Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11beta-hydroxysteroid dehydrogenases. J Nat Prod. 2012 Apr 27;75(4):599-604.
REF 2 Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes. J Med Chem. 2008 Aug 28;51(16):4851-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.