Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52771 | Target Info | |||
| Target Name | Mycobacterium Proton pump (MycB Prop) | ||||
| Synonyms |
Nicotinamide nucleotide transhydrogenase subunit beta; NAD(P) transhydrogenase subunit beta
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| Target Type | Successful Target | ||||
| Gene Name | MycB Prop | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | ||||
| UniProt ID | KCNH2_HUMAN | |||||
| Gene Name | KCNH2 | |||||
| Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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| Representative Drug(s) | Bedaquiline | Drug Info | IC50 = 0.2 ug.mL-1 | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. Bioorg Med Chem. 2015 Feb 15;23(4):742-52. | ||||
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