Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T47623 Target Info
Target Name Heparanase (HPSE)
Synonyms
Hpa1; Heparanase-1; Heparanase 8 kDa subunit; Heparanase 50 kDa subunit; HSE1; HPSE1; HPR1; HPA; HEP protein; Endo-glucoronidase
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Target Type Successful Target
Gene Name HPSE
Biochemical Class Glycosylase
UniProt ID
HPSE_HUMAN
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) Suramin Drug Info IC50 = 18 ug.mL-1 [1]
Co-Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target
UniProt ID SIR1_HUMAN
Gene Name SIRT1
Synonyms
hSIRT1; hSIR2; SIR2L1; SIR2-like protein 1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1
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Representative Drug(s) Suramin Drug Info IC50 = 300 nM [2]
Co-Target Name P2Y purinoceptor 11 (P2RY11) Discontinued Target
UniProt ID P2Y11_HUMAN
Gene Name P2RY11
Synonyms
P2Y11
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Representative Drug(s) Suramin Drug Info Ki = 112.2 nM [3]
References  Top
REF 1 Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54.
REF 2 Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012 Oct 6;3(12):1050-3.
REF 3 Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005 Nov 3;48(22):7040-8.

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