Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42000 | Target Info | |||
| Target Name | Interleukin-1 beta (IL1B) | ||||
| Synonyms |
IL1F2; IL-1beta; IL-1 beta; Catabolin
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| Target Type | Successful Target | ||||
| Gene Name | IL1B | ||||
| Biochemical Class | Cytokine: interleukin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Phosphodiesterase 4A (PDE4A) | Successful Target | ||||
| UniProt ID | PDE4A_HUMAN | |||||
| Gene Name | PDE4A | |||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Type 4A cAMP phosphodiesterase; PDE46; DPDE2
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| Representative Drug(s) | Ibudilast | Drug Info | IC50 = 54 nM | [1] | ||
| Co-Target Name | Phosphodiesterase 4D (PDE4D) | Successful Target | ||||
| UniProt ID | PDE4D_HUMAN | |||||
| Gene Name | PDE4D | |||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D; PDE43; DPDE3
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| Representative Drug(s) | Ibudilast | Drug Info | IC50 = 166 nM | [1] | ||
| Co-Target Name | Phosphodiesterase 4B (PDE4B) | Clinical trial Target | ||||
| UniProt ID | PDE4B_HUMAN | |||||
| Gene Name | PDE4B | |||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Type 4B cAMP phosphodiesterase; Type 4 cyclic adenosine monophosphate phosphodiesterase (type 4 PDE); PDE32; DPDE4
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| Representative Drug(s) | Ibudilast | Drug Info | IC50 = 65 nM | [1] | ||
| Co-Target Name | Phosphodiesterase 4C (PDE4C) | Patented-recorded Target | ||||
| UniProt ID | PDE4C_HUMAN | |||||
| Gene Name | PDE4C | |||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C; PDE21; DPDE1
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| Representative Drug(s) | Ibudilast | Drug Info | IC50 = 239 nM | [1] | ||
| Co-Target Name | N-acylethanolamine-hydrolyzing acidamidase (NAAA) | Literature-reported Target | ||||
| UniProt ID | NAAA_HUMAN | |||||
| Gene Name | NAAA | |||||
| Synonyms |
Nacylsphingosine amidohydrolaselike; Nacylethanolaminehydrolyzing acid amidase subunit beta; NAAA; Acid ceramidaselike protein; ASAHlike protein
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| Representative Drug(s) | Diacerein | Drug Info | IC50 = 700 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. J Med Chem. 2008 Sep 25;51(18):5471-89. | ||||
| REF 2 | Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors. J Med Chem. 2017 Jan 12;60(1):4-46. | ||||
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