Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40696 | Target Info | |||
| Target Name | Staphylococcus Topoisomerase IV (Stap-coc parC) | ||||
| Synonyms |
Topoisomerase IV subunit A; DNA topoisomerase 4 subunit A
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| Target Type | Successful Target | ||||
| Gene Name | Stap-coc parC | ||||
| Biochemical Class | Topoisomerase GyrA ParC | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Bacterial DNA gyrase (Bact gyrase) | Successful Target | ||||
| UniProt ID | GYRA_STAAU; GYRB_STAAU | |||||
| Gene Name | Bact gyrA; Bact gyrB | |||||
| Synonyms |
DNA gyrase
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| Representative Drug(s) | Gatifloxacin | Drug Info | IC50 = 3.22 ug.mL-1 | Click to Show More | [1] | |
| 2 | Ciprofloxacin XR | Drug Info | IC50 = 3.5 ug.mL-1 | [2] | ||
| Co-Target Name | Streptococcus Streptokinase A (Strp ska) | Co-Target | ||||
| UniProt ID | STRP_STRP1 | |||||
| Gene Name | Stap-coc ska | |||||
| Representative Drug(s) | Gatifloxacin | Drug Info | EC50 = 668 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. Bioorg Med Chem. 2009 Oct 1;17(19):6879-89. | ||||
| REF 2 | Design and synthesis of novel 1H-tetrazol-5-amine based potent antimicrobial agents: DNA topoisomerase IV and gyrase affinity evaluation supported by molecular docking studies. Eur J Med Chem. 2018 Aug 5;156:631-640. | ||||
| REF 3 | PubChem BioAssay: 2017 update. Nucleic Acids Res. 2017 Jan 4;45(D1):D955-D963. | ||||
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