Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T28661 | Target Info | |||
Target Name | Tubulin beta-2 chain (TUBB2) | ||||
Synonyms |
Tubulin beta-2A chain; Tubulin beta class IIa; TUBB4B; BetaII-Tubulin; Beta(II)-Tubulin; Beta(II) isotype of Tubulin
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Target Type | Successful Target | ||||
Gene Name | TUBB2A | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Multidrug resistance protein 1 (ABCB1) | Clinical trial Target | ||||
UniProt ID | MDR1_HUMAN | |||||
Gene Name | ABCB1 | |||||
Synonyms |
PGY1; P-glycoprotein 1; MDR1; CD243 antigen; CD243; ATP-binding cassette sub-family B member 1
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Representative Drug(s) | Vinblastine | Drug Info | Ki = 100 nM | [1] | ||
Co-Target Name | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Successful Target | ||||
UniProt ID | POL_HV1B1 | |||||
Gene Name | HIV RT | |||||
Synonyms |
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) | Vinblastine | Drug Info | IC50 ~ 200 ug.mL-1 | [2] |
References | Top | ||||
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REF 1 | Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). J Med Chem. 2002 Dec 19;45(26):5671-86. | ||||
REF 2 | Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54. |
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