Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20808 | Target Info | |||
| Target Name | Isocitrate dehydrogenase (IDH) | ||||
| Synonyms |
Isocitrate dehydrogenase [NAD]
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| Target Type | Successful Target | ||||
| Gene Name | IDH1; IDH2; IDH3A; IDH3B; IDH3G | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Oxalosuccinate decarboxylase (IDH1) | Successful Target | ||||
| UniProt ID | IDHC_HUMAN | |||||
| Gene Name | IDH1 | |||||
| Synonyms |
PICD; NADP(+)-specific ICDH; Isocitrate dehydrogenase [NADP] cytoplasmic; IDP; IDH; Cytosolic NADP-isocitrate dehydrogenase
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| Representative Drug(s) | AG-881 | Drug Info | IC50 = 0.04 nM | [1] | ||
| Co-Target Name | Isocitrate dehydrogenase [NADP] mitochondrial (IDH2) | Co-Target | ||||
| UniProt ID | IDHP_HUMAN | |||||
| Gene Name | IDH2 | |||||
| Synonyms |
Isocitrate dehydrogenase [NADP], mitochondrial; IDH; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
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| Representative Drug(s) | AG-881 | Drug Info | IC50 = 7 nM | Click to Show More | [1] | |
| 2 | AG-221 | Drug Info | IC50 = 9 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective. J Med Chem. 2018 Oct 25;61(20):8981-9003. | ||||
| REF 2 | Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma. ACS Med Chem Lett. 2020 Jan 22;11(2):101-107. | ||||
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