Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K7FT
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| Former ID |
DIB016672
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| Drug Name |
AG-221
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| Synonyms |
AG-221 (IDH2 inhibitor)
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| Indication | Acute myelogenous leukaemia [ICD-11: 2A41; ICD-10: C92.2] | Phase 3 | [1] | |
| Acute myeloid leukaemia [ICD-11: 2A60] | Phase 1/2 | [2] | ||
| Company |
Agios pharmaceuticals; celgene
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| Structure |
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Download2D MOL |
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| Formula |
C19H17F6N7O
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| Canonical SMILES |
CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O
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| InChI |
1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
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| InChIKey |
DYLUUSLLRIQKOE-UHFFFAOYSA-N
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| CAS Number |
CAS 1446502-11-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:145374
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| ADReCS Drug ID | BADD_D02517 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Isocitrate dehydrogenase (IDH) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Citrate cycle (TCA cycle) | |||
| Glutathione metabolism | ||||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Carbon metabolism | ||||
| 2-Oxocarboxylic acid metabolism | ||||
| Biosynthesis of amino acids | ||||
| Peroxisome | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| WikiPathways | TCA Cycle | |||
| The citric acid (TCA) cycle and respiratory electron transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT02273739) Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation. U.S.National Institutes of Health. | |||
| REF 3 | New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma. Int J Med Sci. 2015; 12(3): 201-213. | |||
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