Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T14908 Target Info
Target Name Ceramide glucosyltransferase (UGCG)
Synonyms
UGCG; UDP-glucose:N-acylsphingosine D-glucosyltransferase; UDP-glucose ceramideglucosyltransferase; Glucosylceramide synthase; GLCT-1
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Target Type Successful Target
Gene Name UGCG
Biochemical Class Hexosyltransferase
UniProt ID
CEGT_HUMAN
Co-Targets of This Target  Top
Co-Target Name Lysosomal alpha-glucosidase (GAA) Successful Target
UniProt ID LYAG_HUMAN
Gene Name GAA
Synonyms
GAA; Aglucosidase alfa; Acid maltase
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Representative Drug(s) Miglustat Drug Info IC50 = 100 nM [1]
Co-Target Name Beta-glucosidase 2 (GBA2) Co-Target
UniProt ID GBA2_HUMAN
Gene Name GBA2
Synonyms
Non-lysosomal glucosylceramidase; NLGase; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; Beta-glucocerebrosidase 2; Glucosylceramidase 2
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Representative Drug(s) Miglustat Drug Info IC50 = 14 nM [2]
Co-Target Name Sucrase-isomaltase (SI) Co-Target
UniProt ID SUIS_HUMAN
Gene Name SI
Synonyms
Sucrase-isomaltase, intestinal
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Representative Drug(s) Miglustat Drug Info IC50 = 500 nM [3]
References  Top
REF 1 Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3.
REF 2 Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. Eur J Med Chem. 2019 Aug 1;175:63-71.
REF 3 Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010 Jan 28;53(2):689-98.

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