Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T14731 | Target Info | |||
Target Name | NAD-dependent deacetylase sirtuin-1 (SIRT1) | ||||
Synonyms |
hSIRT1; hSIR2; SIR2L1; SIR2-like protein 1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1
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Target Type | Clinical trial Target | ||||
Gene Name | SIRT1 | ||||
Biochemical Class | Carbon-nitrogen hydrolase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Dipeptidyl peptidase 4 (DPP-4) | Successful Target | ||||
UniProt ID | DPP4_HUMAN | |||||
Gene Name | DPP4 | |||||
Synonyms |
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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Representative Drug(s) | Resveratrol | Drug Info | IC50 = 0.6 nM | [1] | ||
Co-Target Name | Aromatase (CYP19A1) | Successful Target | ||||
UniProt ID | CP19A_HUMAN | |||||
Gene Name | CYP19A1 | |||||
Synonyms |
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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Representative Drug(s) | Resveratrol | Drug Info | IC50 ~ 40 ug.mL-1 | [2] | ||
Co-Target Name | Quinone reductase 2 (NQO2) | Successful Target | ||||
UniProt ID | NQO2_HUMAN | |||||
Gene Name | NQO2 | |||||
Synonyms |
Quinone oxidoreductase 2; Qui reductase 2; QR2; NRH:quinone oxidoreductase 2; NRH:qui oxidoreductase 2; NQO2; NAD(P)H qui oxidoreductase 2
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Representative Drug(s) | Resveratrol | Drug Info | Ki = 88 nM | [3] | ||
Co-Target Name | PI3-kinase alpha (PIK3CA) | Successful Target | ||||
UniProt ID | PK3CA_HUMAN | |||||
Gene Name | PIK3CA | |||||
Synonyms |
p110alpha; Serine/threonine protein kinase PIK3CA; PtdIns3kinase subunit p110alpha; PtdIns3kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; PtdIns-3-kinase subunit alpha; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PI3kinase subunit alpha; PI3Kalpha; PI3K-alpha; PI3-kinase subunit alpha
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Representative Drug(s) | Resveratrol | Drug Info | IC50 = 250 nM | [4] | ||
Co-Target Name | Prostaglandin G/H synthase 2 (COX-2) | Successful Target | ||||
UniProt ID | PGH2_HUMAN | |||||
Gene Name | PTGS2 | |||||
Synonyms |
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2
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Representative Drug(s) | Resveratrol | Drug Info | IC50 = 750 nM | [5] | ||
Co-Target Name | Transformation-sensitive protein p120 (TRPA1) | Successful Target | ||||
UniProt ID | TRPA1_HUMAN | |||||
Gene Name | TRPA1 | |||||
Synonyms |
TRPA1; Ankyrin-like with transmembrane domains protein 1; ANKTM1
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Representative Drug(s) | Resveratrol | Drug Info | IC50 = 750 nM | [6] | ||
Co-Target Name | Estrogen receptor (ESR) | Successful Target | ||||
UniProt ID | ESR1_HUMAN | |||||
Gene Name | ESR1 | |||||
Synonyms |
Nuclear receptor subfamily 3 group A member 1; NR3A1; Estradiol receptor; ESR; ER-alpha; ER
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Representative Drug(s) | Resveratrol | Drug Info | Ki = 785 nM | [7] | ||
Co-Target Name | Prostaglandin G/H synthase 1 (COX-1) | Successful Target | ||||
UniProt ID | PGH1_HUMAN | |||||
Gene Name | PTGS1 | |||||
Synonyms |
Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PHS 1; PGHS-1; PGH synthase 1; Cyclooxygenase-1; COX1; COX-1
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Representative Drug(s) | Resveratrol | Drug Info | IC50 = 830 nM | [8] | ||
Co-Target Name | Carbonic anhydrase XIV (CA-XIV) | Successful Target | ||||
UniProt ID | CAH14_HUMAN | |||||
Gene Name | CA14 | |||||
Synonyms |
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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Representative Drug(s) | Resveratrol | Drug Info | Ki = 830 nM | [9] | ||
Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
UniProt ID | CAH12_HUMAN | |||||
Gene Name | CA12 | |||||
Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) | Resveratrol | Drug Info | Ki = 950 nM | [9] | ||
Co-Target Name | PI3-kinase beta (PIK3CB) | Clinical trial Target | ||||
UniProt ID | PK3CB_HUMAN | |||||
Gene Name | PIK3CB | |||||
Synonyms |
p110beta; PtdIns3kinase subunit p110beta; PtdIns3kinase subunit beta; PtdIns-3-kinase subunit p110-beta; PtdIns-3-kinase subunit beta; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunitbeta isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalyticsubunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PIK3C1; PI3kinase subunit beta; PI3Kbeta; PI3K-beta; PI3-kinase subunit beta
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Representative Drug(s) | Resveratrol | Drug Info | IC50 = 500 nM | [4] | ||
Co-Target Name | Cytochrome P450 1B1 (CYP1B1) | Clinical trial Target | ||||
UniProt ID | CP1B1_HUMAN | |||||
Gene Name | CYP1B1 | |||||
Synonyms |
CYPIB1
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Representative Drug(s) | Resveratrol | Drug Info | Ki = 750 nM | [10] | ||
Co-Target Name | Carbonic anhydrase IX (CA-IX) | Clinical trial Target | ||||
UniProt ID | CAH9_HUMAN | |||||
Gene Name | CA9 | |||||
Synonyms |
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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Representative Drug(s) | Resveratrol | Drug Info | Ki = 810 nM | [9] | ||
Co-Target Name | NAD-dependent deacetylase sirtuin-2 (SIRT2) | Patented-recorded Target | ||||
UniProt ID | SIR2_HUMAN | |||||
Gene Name | SIRT2 | |||||
Synonyms |
SIR2like protein 2; SIR2L2; SIR2L; SIR2-like protein 2; Regulatory protein SIR2 homolog 2; NADdependent protein deacetylase sirtuin2; NAD-dependent protein deacetylase sirtuin-2
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Representative Drug(s) | SEN-196 | Drug Info | IC50 = 98 nM | [11] |
References | Top | ||||
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REF 1 | Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2018 May 10;151:145-157. | ||||
REF 2 | Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. | ||||
REF 3 | Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorg Med Chem. 2013 Oct 1;21(19):6022-37. | ||||
REF 4 | Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55. | ||||
REF 5 | Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. | ||||
REF 6 | Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3167-72. | ||||
REF 7 | Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. | ||||
REF 8 | Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. Bioorg Med Chem. 2009 Feb 1;17(3):1044-54. | ||||
REF 9 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. | ||||
REF 10 | Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1. Eur J Med Chem. 2019 Feb 1;163:28-36. | ||||
REF 11 | Development of second generation epigenetic agents. Medchemcomm. 2012;3:135-61. |
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