Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13127 | Target Info | |||
| Target Name | Farnesyl protein transferase (Ftase) | ||||
| Synonyms |
Ras proteins prenyltransferase; Protein farnesyltransferase; Ftase; CAAX farnesyltransferase
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| Target Type | Successful Target | ||||
| Gene Name | FNTB; FNTA | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | GTPase HRas (HRAS) | Literature-reported Target | ||||
| UniProt ID | RASH_HUMAN | |||||
| Gene Name | HRAS | |||||
| Synonyms |
p21ras; cHras; c-H-ras; Transforming protein p21; HaRas; Ha-Ras; H-Ras-1; GTPase HRas, Nterminally processed
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| Representative Drug(s) | Lonafarnib | Drug Info | IC50 = 70 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent. J Med Chem. 1998 Nov 19;41(24):4890-902. | ||||
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