Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T11448 Target Info
Target Name Adrenergic receptor alpha-2A (ADRA2A)
Synonyms
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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Target Type Successful Target
Gene Name ADRA2A
Biochemical Class GPCR rhodopsin
UniProt ID
ADA2A_HUMAN
Co-Targets of This Target  Top
Co-Target Name Adrenergic receptor alpha-2C (ADRA2C) Successful Target
UniProt ID ADA2C_HUMAN
Gene Name ADRA2C
Synonyms
Subtype C4; Alpha-2CAR; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; ADRA2RL2; ADRA2L2
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Representative Drug(s) Lofexidine Drug Info EC50 = 1.38 nM [1]
Co-Target Name Adrenergic receptor alpha-2B (ADRA2B) Successful Target
UniProt ID ADA2B_HUMAN
Gene Name ADRA2B
Synonyms
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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Representative Drug(s) Lofexidine Drug Info Ki = 67.61 nM [1]
Co-Target Name 5-HT 1A receptor (HTR1A) Successful Target
UniProt ID 5HT1A_HUMAN
Gene Name HTR1A
Synonyms
Serotonin receptor 1A; G-21; ADRBRL1; ADRB2RL1; 5-hydroxytryptamine receptor 1A; 5-HT1A receptor; 5-HT1A; 5-HT-1A
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Representative Drug(s) Lofexidine Drug Info Ki = 125.89 nM [2]
Co-Target Name Imidazoline receptor 1 (IR1) Literature-reported Target
UniProt ID NISCH_HUMAN
Gene Name NISCH
Synonyms
hIRAS; KIAA0975; Imidazoline-1 receptor candidate protein; Imidazoline-1 receptor; Imidazoline receptor antisera-selected protein; IRAS; IR1; I1R candidate protein; I-1 receptor candidate protein; I-1
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Representative Drug(s) MOXONIDINE Drug Info IC50 = 3.548 nM [3]
References  Top
REF 1 Might the observed alpha(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? Bioorg Med Chem. 2012 Mar 15;20(6):2082-90.
REF 2 Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. ACS Med Chem Lett. 2012 Jun 8;3(7):535-9.
REF 3 Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I 2 Receptor Ligands for Alzheimer's Disease. J Med Chem. 2020 Apr 9;63(7):3610-3633.

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