Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T09909 | Target Info | |||
| Target Name | Angiotensin II receptor type-2 (AGTR2) | ||||
| Synonyms |
Type-2 angiotensin II receptor; Angiotensin II type-2 receptor; Angiotensin II receptor 2; AT2
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| Target Type | Successful Target | ||||
| Gene Name | AGTR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Angiotensin II receptor type-1 (AGTR1) | Successful Target | ||||
| UniProt ID | AGTR1_HUMAN | |||||
| Gene Name | AGTR1 | |||||
| Synonyms |
Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; Angiotensin II receptor 1; Angiotensin 1 receptor; AT2R1B; AT2R1; AT1BR; AT1AR; AT1; AGTR1B; AGTR1A
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| Representative Drug(s) | ANGIOTENSIN II | Drug Info | Ki = 0.16 nM | Click to Show More | [1] | |
| 2 | SARALASIN | Drug Info | Ki = 0.17 nM | [2] | ||
| 3 | EMA-401 | Drug Info | IC50 = 39 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mimicking of Arginine by Functionalized N(omega)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples. J Med Chem. 2016 Mar 10;59(5):1925-45. | ||||
| REF 2 | Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. Eur J Med Chem. 2013 May;63:85-94. | ||||
| REF 3 | The Other Angiotensin II Receptor: AT 2 R as a Therapeutic Target. J Med Chem. 2020 Mar 12;63(5):1978-1995. | ||||
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