Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G6SE
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| Former ID |
DNC010605
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| Drug Name |
ANGIOTENSIN II
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| Synonyms |
Human angiotensin II; Angiotensin II human; 4474-91-3; Angiotensin II (mouse); Angiotensin II (human); Giapreza; Ang II; 5-Isoleucine-angiotensin II; 5-L-Isoleucineangiotensin II; Ile(5)-angiotensin II; 1-8-Angiotensin I; isoleucine(5)-angiotensin II;Angiotensin II, human; Isoleucine5-angiotensin II; Angiotensin II, ile(5)-; Angiotensin ii [INN:JAN]
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| Drug Type |
Small molecular drug
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| Indication | Increase blood pressure [ICD-11: BA04] | Approved | [1] | |
| Company |
La Jolla Pharmaceutical Company
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| Structure |
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Download2D MOL |
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| Formula |
C50H71N13O12
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| Canonical SMILES |
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
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| InChI |
1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
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| InChIKey |
CZGUSIXMZVURDU-JZXHSEFVSA-N
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| CAS Number |
CAS 4474-91-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5214, 835296, 841812, 7849076, 14816795, 14914641, 16177615, 33496888, 49658676, 50112427, 53801076, 57352135, 75293214, 104056366, 113472121, 126523759, 126691187, 137002489, 137239438, 160704000, 162249914, 163414066, 163423859, 163849090, 164779216, 179293086, 184605754, 184605755, 189614599, 224120639, 226394001, 234463367, 241182183, 249827117, 250135355, 251887200, 252057329
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| ChEBI ID |
CHEBI:2719
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. | |||
| REF 2 | The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. | |||
| REF 3 | The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993). | |||
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