Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06455 | Target Info | |||
| Target Name | Cytochrome P450 2A6 (CYP2A6) | ||||
| Synonyms |
Cytochrome P450(I); Cytochrome P450 IIA3; Coumarin 7-hydroxylase; CYPIIA6; CYP2A6; CYP2A3
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| Target Type | Successful Target | ||||
| Gene Name | CYP2A6 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Acetylcholinesterase (AChE) | Successful Target | ||||
| UniProt ID | ACES_HUMAN | |||||
| Gene Name | ACHE | |||||
| Synonyms |
YT; N-ACHE; ARACHE
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| Representative Drug(s) | Methoxsalen | Drug Info | IC50 = 760 nM | [1] | ||
| Co-Target Name | Cytochrome P450 2A13 (CYP2A13) | Co-Target | ||||
| UniProt ID | CP2AD_HUMAN | |||||
| Gene Name | CYP2A13 | |||||
| Synonyms |
CYPIIA13
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| Representative Drug(s) | Methoxsalen | Drug Info | Ki = 40 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4248-52. | ||||
| REF 2 | Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. Drug Metab Dispos. 2012 Sep;40(9):1797-802. | ||||
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