Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05152 | Target Info | |||
| Target Name | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | ||||
| Synonyms |
HCV NS5B; HCV p68
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| Target Type | Successful Target | ||||
| Gene Name | HCV NS5B | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Hepatitis C virus Non-structural 5A (HCV NS5A) | Successful Target | ||||
| UniProt ID | POLG_HCV1 (1973-2420) | |||||
| Gene Name | HCV NS5A | |||||
| Synonyms |
HCV NS5A
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| Representative Drug(s) | VX-222 | Drug Info | EC50 = 7 nM | [1] | ||
| Co-Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | ||||
| UniProt ID | KCNH2_HUMAN | |||||
| Gene Name | KCNH2 | |||||
| Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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| Representative Drug(s) | Tegobuvir | Drug Info | IC50 = 794.33 nM | [2] | ||
| References | Top | ||||
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| REF 1 | Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles. J Med Chem. 2016 Jul 14;59(13):6293-302. | ||||
| REF 2 | Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B. Bioorg Med Chem. 2018 May 15;26(9):2621-31. | ||||
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