Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F4NH
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| Former ID |
DCL001253
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| Drug Name |
VX-222
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| Synonyms |
VX-222; Lomibuvir; 1026785-59-0; 1026785-55-6; VX 222; VX-222 (VCH-222, Lomibuvir); UNII-37L2LF4A2D; VCH222; VCH-222; VX222; 37L2LF4A2D; Lomibuvir (VX-222, VCH-222); 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-;2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Phase 2 | [1] | |
| Company |
Vertex
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H35NO4S
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| Canonical SMILES |
CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
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| InChI |
1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)
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| InChIKey |
WPMJNLCLKAKMLA-UHFFFAOYSA-N
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| CAS Number |
CAS 1026785-55-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
49743177, 56330614, 99437284, 124757282, 125164086, 125748803, 126661320, 126731534, 131480892, 135300680, 136340218, 136367439, 138241390, 141916436, 152258905, 162011887, 162037623, 162108754, 162202730, 163477878, 163501415, 163670882, 163675562, 163686469, 164193944, 172232518, 172919862, 174007365, 174520431, 174525828, 177748963, 184816771, 188899556, 198943658, 223653165, 223713664, 224226211, 224226230, 224470751, 226476638, 226502253, 226502609, 240441298, 240820934, 240820937, 240885528, 242060096, 242585965, 244626635, 245968072
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| ChEBI ID |
CHEBI:94757
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2011 Pipeline of Vertex. | |||
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