Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T05114 Target Info
Target Name Chymase (CYM)
Synonyms
Mast cell protease I; CYH; Alpha-chymase
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Target Type Clinical trial Target
Gene Name CMA1
Biochemical Class Peptidase
UniProt ID
CMA1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Opioid receptor sigma 1 (OPRS1) Successful Target
UniProt ID SGMR1_HUMAN
Gene Name SIGMAR1
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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Representative Drug(s) SUN13834 Drug Info Ki = 0.83 nM [1]
Co-Target Name Debrisoquine 4-hydroxylase (CYP2D6) Successful Target
UniProt ID CP2D6_HUMAN
Gene Name CYP2D6
Synonyms
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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Representative Drug(s) SUN13834 Drug Info Ki = 170 nM [2]
Co-Target Name Cathepsin G (CTSG) Clinical trial Target
UniProt ID CATG_HUMAN
Gene Name CTSG
Synonyms
CG
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Representative Drug(s) JNJ-10311795 Drug Info Ki = 38 nM [3]
Co-Target Name Cholestenol delta-isomerase (EBP) Clinical trial Target
UniProt ID EBP_HUMAN
Gene Name EBP
Synonyms
Emopamilbinding protein; EBP; Delta(8)Delta(7) sterol isomerase; D8D7 sterol isomerase; 3betahydroxysteroidDelta(8),Delta(7)isomerase
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Representative Drug(s) SUN13834 Drug Info Ki = 165 nM [1]
References  Top
REF 1 Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem. 2005 Jul 28;48(15):4754-64.
REF 2 Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45.
REF 3 Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.

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