Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T05089 Target Info
Target Name Calcium-dependent chloride channel anoctamin (ANO)
Synonyms
Tumoramplified and overexpressed sequence 2; Tumor-amplified and overexpressed sequence 2; Transmembrane protein 16A; TMEM16A; TAOS2; Oral cancer overexpressed protein 2; ORAOV2; Discovered on gastrointestinal stromal tumors protein 1; DOG1; Anoctamin1; Anoctamin-1
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Target Type Successful Target
Gene Name ANO1
UniProt ID
ANO1_HUMAN
Co-Targets of This Target  Top
Co-Target Name S-mephenytoin 4-hydroxylase (CYP2C9) Successful Target
UniProt ID CP2C9_HUMAN
Gene Name CYP2C9
Synonyms
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
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Representative Drug(s) Benzbromarone Drug Info Ki = 19 nM [1]
Co-Target Name Urate anion exchanger 1 (URAT1) Successful Target
UniProt ID S22AC_HUMAN
Gene Name SLC22A12
Synonyms
UNQ6453/PRO34004; Solute carrier family 22 member 12; Renal-specific transporter; RST; Organic anion transporter 4-like protein; OATL4
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Representative Drug(s) Benzbromarone Drug Info IC50 = 22 nM [2]
Co-Target Name Multidrug resistance-associated protein 1 (ABCC1) Successful Target
UniProt ID MRP1_HUMAN
Gene Name ABCC1
Synonyms
MRP1; MRP; Leukotriene C(4) transporter; LTC4 transporter; ATP-binding cassette sub-family C member 1
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Representative Drug(s) Benzbromarone Drug Info Ki = 190 nM [3]
Co-Target Name Aldo-keto reductase family 1 member C1 (AK1C1_HUMAN) Co-Target
UniProt ID AK1C1_HUMAN
Gene Name AKR1C1
Synonyms
20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD1; Chlordecone reductase homolog HAKRC; High-affinity hepatic bile acid-binding protein; HBAB
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Representative Drug(s) Benzbromarone Drug Info IC50 = 48 nM [4]
References  Top
REF 1 Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors. J Med Chem. 2004 Dec 30;47(27):6768-76.
REF 2 The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. Medchemcomm. 2016;7:1587-95.
REF 3 Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors. Bioorg Med Chem. 2011 May 15;19(10):3249-54.
REF 4 Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20... J Med Chem. 2009 May 28;52(10):3259-64.

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