Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04689 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-1 (CHRNA1) | ||||
| Synonyms |
CHNRA; Acetylcholine receptor subunit alpha; ACHRA
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| Target Type | Successful Target | ||||
| Gene Name | CHRNA1 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Acetylcholinesterase (AChE) | Successful Target | ||||
| UniProt ID | ACES_HUMAN | |||||
| Gene Name | ACHE | |||||
| Synonyms |
YT; N-ACHE; ARACHE
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| Representative Drug(s) | Decamethonium | Drug Info | IC50 = 1000 nM | [1] | ||
| Co-Target Name | Histamine H3 receptor (H3R) | Clinical trial Target | ||||
| UniProt ID | HRH3_HUMAN | |||||
| Gene Name | HRH3 | |||||
| Synonyms |
Histamine receptor 3; HH3R; GPCR97; G-protein coupled receptor 97; G protein-coupled receptor 97
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| Representative Drug(s) | Decamethonium | Drug Info | IC50 = 820 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Biased and unbiased strategies to identify biologically active small molecules. Bioorg Med Chem. 2014 Aug 15;22(16):4474-89. | ||||
| REF 2 | Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorg Med Chem. 2008 Mar 15;16(6):2968-73. | ||||
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