Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T03403 Target Info
Target Name Prostaglandin G/H synthase (COX)
Synonyms
Prostaglandin-endoperoxide synthase; Prostaglandin H2 synthase; PHS; PGHS; PGH synthase; Cyclooxygenase; COX
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Target Type Successful Target
Gene Name PTGS1; PTGS2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
PGH1_HUMAN; PGH2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Interleukin-8 (IL8) Successful Target
UniProt ID IL8_HUMAN
Gene Name CXCL8
Synonyms
T-cell chemotactic factor; Protein 3-10C; Neutrophil-activating protein 1; NAP-1; Monocyte-derived neutrophil-activating peptide; Monocyte-derived neutrophil chemotactic factor; MONAP; MDNCF; IL8; IL-8; Granulocyte chemotactic protein 1; GCP-1; Emoctakin; Chemokine (C-X-C motif) ligand 8; C-X-C motif chemokine 8
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Representative Drug(s) Diclofenac Drug Info IC50 = 8 nM [1]
Co-Target Name C-X-C chemokine receptor type 1 (CXCR1) Successful Target
UniProt ID CXCR1_HUMAN
Gene Name CXCR1
Synonyms
Interleukin-8 receptor A; IL8RA; IL-8R A; IL-8 receptor type 1; High affinity interleukin-8 receptor A; CXCR-1; CXC-R1; CMKAR1; CDw128a; CD181
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Representative Drug(s) Diclofenac Drug Info IC50 = 12 nM [1]
Co-Target Name Dihydrodiol dehydrogenase type I (AKR1C3) Successful Target
UniProt ID AK1C3_HUMAN
Gene Name AKR1C3
Synonyms
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Testosterone 17-beta-dehydrogenase 5; Prostaglandin F synthase; PGFS; KIAA0119; Indanol dehydrogenase; HSD17B5; HA1753; Dihydrodiol dehydrogenase 3; DDH1; DD3; DD-3; Chlordecone reductase homolog HAKRb; Aldo-keto reductase family 1 member C3; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type II, brain; 3-alpha-HSD type 2; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5
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Representative Drug(s) Meclofenamic acid Drug Info IC50 = 512 nM [2]
Co-Target Name Interleukin 8 receptor (IL8R) Literature-reported Target
UniProt ID CXCR1_HUMAN; CXCR2_HUMAN
Gene Name CXCR1; CXCR2
Synonyms
IL8R; IL-8R; IL-8 receptor; High affinity interleukin-8 receptor; CXCR; CXC-R; CDw128
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Representative Drug(s) Dexibuprofen Drug Info IC50 = 100 nM [3]
Co-Target Name Nicotinate phosphoribosyltransferase (NAPRT) Co-Target
UniProt ID PNCB_HUMAN
Gene Name NAPRT
Synonyms
NAPRTase; FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1
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Representative Drug(s) Aspirin Drug Info Ki = 0.5 nM [4]
Co-Target Name Aldo-keto reductase family 1 member C1 (AK1C1_HUMAN) Co-Target
UniProt ID AK1C1_HUMAN
Gene Name AKR1C1
Synonyms
20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Dihydrodiol dehydrogenase 1; DD1; Chlordecone reductase homolog HAKRC; High-affinity hepatic bile acid-binding protein; HBAB
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Representative Drug(s) Meclofenamic acid Drug Info IC50 = 740 nM [2]
References  Top
REF 1 Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
REF 2 Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors. Bioorg Med Chem. 2018 Dec 1;26(22):5934-43.
REF 3 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
REF 4 WHO patent application no. 2017162840A1, SENSITIZATION OF CANCER CELLS TO NAMPT INHIBITORS BY NICOTINIC ACID PHOSPHORIBOSYLTRANSFERASE NEUTRALIZATION.

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