Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01318 | Target Info | |||
| Target Name | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | ||||
| Synonyms |
PFF0160c; Mitochondrially bound dihydroorotate-ubiqui oxidoreductase; Dihydroorotate oxidase of Plasmodium falciparum; Dihydroorotate dehydrogenase of Plasmodium falciparum; DHOdehase of Plasmodium falciparum; DHODase; DHODH of Plasmodium falciparum; DHOD
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| Target Type | Successful Target | ||||
| Gene Name | Malaria DHOdehase | ||||
| Biochemical Class | CH-CH donor oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Indoleamine 2,3-dioxygenase 1 (IDO1) | Successful Target | ||||
| UniProt ID | I23O1_HUMAN | |||||
| Gene Name | IDO1 | |||||
| Synonyms |
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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| Representative Drug(s) | Avastin+/-Tarceva | Drug Info | IC50 = 1000 nM | [1] | ||
| Co-Target Name | Cytochrome P450 1A2 (CYP1A2) | Co-Target | ||||
| UniProt ID | CP1A2_HUMAN | |||||
| Gene Name | CYP1A2 | |||||
| Synonyms |
Cholesterol 25-hydroxylase; Hydroperoxy icosatetraenoate dehydratase; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3
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| Representative Drug(s) | Leflunomide | Drug Info | IC50 = 500 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. | ||||
| REF 2 | DrugMatrix in vitro pharmacology data. National Toxicology Program | ||||
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