Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T00158 | Target Info | |||
Target Name | HUMAN glycosylation of host receptor (GHR) |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Toll-like receptor 7 (TLR7) | Successful Target | ||||
UniProt ID | TLR7_HUMAN | |||||
Gene Name | TLR7 | |||||
Synonyms |
Toll-like receptor 7
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Representative Drug(s) | Hydroxychloroquine | Drug Info | IC50 = 800 nM | [1] | ||
Co-Target Name | Toll-like receptor 9 (TLR9) | Clinical trial Target | ||||
UniProt ID | TLR9_HUMAN | |||||
Gene Name | TLR9 | |||||
Synonyms |
UNQ5798/PRO19605; TLR-9; CD289
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Representative Drug(s) | Hydroxychloroquine | Drug Info | IC50 = 110 nM | [1] | ||
Co-Target Name | Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) | Literature-reported Target | ||||
UniProt ID | Q9N6S8_PLAFA | |||||
Gene Name | Malaria CPF2 | |||||
Synonyms |
Falcipain 2; Cysteine proteinase falcipain 2a
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Representative Drug(s) | Chloroquine | Drug Info | IC50 = 20 nM | [2] |
References | Top | ||||
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REF 1 | Activity-guided development of potent and selective toll-like receptor 9 antagonists. Eur J Med Chem. 2018 Nov 5;159:187-205. | ||||
REF 2 | Designing novel inhibitors against falcipain-2 of Plasmodium falciparum. Bioorg Med Chem Lett. 2018 May 15;28(9):1566-1569. |
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