Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00145 | Target Info | |||
| Target Name | HUMAN pH-dependent viral fusion/replication (pH-DVF/R) | ||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Toll-like receptor 7 (TLR7) | Successful Target | ||||
| UniProt ID | TLR7_HUMAN | |||||
| Gene Name | TLR7 | |||||
| Synonyms |
Toll-like receptor 7
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| Representative Drug(s) | Hydroxychloroquine | Drug Info | IC50 = 800 nM | [1] | ||
| Co-Target Name | Toll-like receptor 9 (TLR9) | Clinical trial Target | ||||
| UniProt ID | TLR9_HUMAN | |||||
| Gene Name | TLR9 | |||||
| Synonyms |
UNQ5798/PRO19605; TLR-9; CD289
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| Representative Drug(s) | Hydroxychloroquine | Drug Info | IC50 = 110 nM | [1] | ||
| Co-Target Name | Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) | Literature-reported Target | ||||
| UniProt ID | Q9N6S8_PLAFA | |||||
| Gene Name | Malaria CPF2 | |||||
| Synonyms |
Falcipain 2; Cysteine proteinase falcipain 2a
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| Representative Drug(s) | Chloroquine | Drug Info | IC50 = 20 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Activity-guided development of potent and selective toll-like receptor 9 antagonists. Eur J Med Chem. 2018 Nov 5;159:187-205. | ||||
| REF 2 | Designing novel inhibitors against falcipain-2 of Plasmodium falciparum. Bioorg Med Chem Lett. 2018 May 15;28(9):1566-1569. | ||||
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