Target Validation Information
Target ID T16308
Target Name Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Target Type
Research
Drug Potency against Target Ac-Phe-Thr(PO3H2)-Pip-Nal-Gln-NH2 Drug Info Ki = 547 nM [528104]
(R)-2-(2-naphthamido)-3-m-tolylpropanoic acid Drug Info Ki = 2800 nM [530771]
(R)-2-(2-naphthamido)-3-p-tolylpropanoic acid Drug Info Ki = 17000 nM [530771]
(R)-3-(2-naphthamido)-4-m-tolylbutanoic acid Drug Info Ki = 9700 nM [530771]
(R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid Drug Info Ki = 12800 nM [530771]
(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid Drug Info Ki = 1800 nM [530771]
Ac-Phe-D-Thr(PO3H2)-Pip-Nal-Gln-NH2 Drug Info Ki = 18.3 nM [528104]
Ac-Bth-Thr(PO3H2)-Pip-Nal-Gln-NH2 Drug Info Ki = 258 nM [528104]
References
Ref 528104J Med Chem. 2006 Apr 6;49(7):2147-50.Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries.
Ref 530771Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).
Ref 530771Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).
Ref 530771Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).
Ref 530771Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).
Ref 530771Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).
Ref 528104J Med Chem. 2006 Apr 6;49(7):2147-50.Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries.
Ref 528104J Med Chem. 2006 Apr 6;49(7):2147-50.Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries.

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