Target Validation Information
Target ID T16514
Target Name Fatty acid synthase
Target Type
Successful
Drug Potency against Target Cerulenin Drug Info IC50 = 1 mol [553122]
2-Hexadecynoic acid Drug Info Ki = 4800 nM [531170]
BIOCHANIN Drug Info IC50 = 8000 nM [528213]
(-)-CATECHINGALLATE Drug Info Ki = 2800 nM [528213]
GALLOCATECHIN GALLATE Drug Info IC50 = 600 nM [528213]
4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one Drug Info IC50 = 3000 nM [528261]
4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one Drug Info IC50 = 550 nM [528261]
EPIGALOCATECHIN GALLATE Drug Info IC50 = 400 nM [528213]
MORIN Drug Info IC50 = 8000 nM [528213]
FISETIN Drug Info IC50 = 2000 nM [528213]
References
Ref 553122Binding site of cerulenin in fatty acid synthetase. J Biochem. 1989 May;105(5):751-5.
Ref 531170Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528261Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. Epub 2006 Jun 19.3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Ref 528261Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. Epub 2006 Jun 19.3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

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