Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0RB1V
|
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| Former ID |
DNC004629
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| Drug Name |
(-)-CATECHINGALLATE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C22H18O10
|
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| Canonical SMILES |
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC<br />(=C(C(=C4)O)O)O
|
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| InChI |
1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2
|
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| InChIKey |
LSHVYAFMTMFKBA-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Fatty acid synthase | Target Info | Inhibitor | [2] | |
| Beta-secretase | Target Info | Inhibitor | [1] | ||
| Beta-hydroxyacyl-acp dehydratase | Target Info | Inhibitor | [2] | ||
| Enoyl-ACP reductase | Target Info | Inhibitor | [2] | ||
| 3-oxoacyl-[acyl-carrier protein] reductase | Target Info | Inhibitor | [2] | ||
| BioCyc Pathway | Fatty acid biosynthesis initiation | ||||
| Fatty acid elongation -- saturated | |||||
| Palmitate biosynthesis | |||||
| KEGG Pathway | Fatty acid biosynthesis | ||||
| Metabolic pathways | |||||
| Fatty acid metabolism | |||||
| AMPK signaling pathway | |||||
| Insulin signaling pathwaypfa00061:Fatty acid biosynthesis | |||||
| Biotin metabolism | |||||
| Metabolic pathways | |||||
| Fatty acid metabolism | |||||
| Pathway Interaction Database | p73 transcription factor network | ||||
| Validated transcriptional targets of deltaNp63 isoforms | |||||
| PathWhiz Pathway | Fatty Acid Biosynthesis | ||||
| Reactome | ChREBP activates metabolic gene expression | ||||
| Activation of gene expression by SREBF (SREBP) | |||||
| Fatty Acyl-CoA Biosynthesis | |||||
| WikiPathways | Fatty Acid Biosynthesis | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Liver X Receptor Pathway | |||||
| Activation of Gene Expression by SREBP (SREBF) | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| SREBP signalling | |||||
| Metabolism of water-soluble vitamins and cofactors | |||||
| Integration of energy metabolism | |||||
| Fatty acid, triacylglycerol, and ketone body metabolism | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2003 Nov 17;13(22):3905-8.Green tea catechins as a BACE1 (beta-secretase) inhibitor. | ||||
| REF 2 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
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