| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T65501 | ||||
| Target Name | DNA (cytosine-5)-methyltransferase 3B | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | S-tubercidinylhomocysteine | Drug Info | IC50 = 300 nM | [1] | |
| S-Adenosylhomocysteine | Drug Info | IC50 = 250 nM | [2] | ||
| NSC-622445 | Drug Info | IC50 = 17000 nM | [2] | ||
| (L-)-S-adenosyl-L-homocysteine | Drug Info | IC50 = 200 nM | [3] | ||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. Epub 2009 Mar 28.SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. | ||||
| REF 2 | Bioorg Med Chem. 2010 Jan 15;18(2):822-9. Epub 2009 Nov 27.Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. | ||||
| REF 3 | Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. Epub 2009 Mar 28.Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. | ||||
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