Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09LTD
|
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| Former ID |
DNC010388
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| Drug Name |
S-Adenosylhomocysteine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H20N6O5S
|
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| InChI |
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
|
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| InChIKey |
ZJUKTBDSGOFHSH-WFMPWKQPSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3323, 583706, 583777, 584107, 584139, 584141, 584232, 585665, 585667, 819481, 821985, 822326, 823446, 823671, 823674, 823752, 823759, 823760, 825350, 825508, 826328, 826704, 826886, 826998, 827321, 827323, 827986, 828015, 828895, 828902, 828903, 829090, 829123, 829143, 829144, 829374, 829461, 829592, 829987, 830206, 830218, 831397, 831420, 831802, 831805, 831823, 832715, 832826, 833169, 833170
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| Target and Pathway | |||||
| Target(s) | DNA (cytosine-5)-methyltransferase | Target Info | Inhibitor | [2] | |
| DNA (cytosine-5)-methyltransferase 3B | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Cysteine and methionine metabolism | ||||
| Metabolic pathways | |||||
| MicroRNAs in cancer | |||||
| Reactome | PRC2 methylates histones and DNA | ||||
| NoRC negatively regulates rRNA expression | |||||
| DNA methylation | |||||
| WikiPathways | Mesodermal Commitment Pathway | ||||
| Endoderm Differentiation | |||||
| Trans-sulfuration and one carbon metabolism | |||||
| One Carbon Metabolism | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5265). | ||||
| REF 2 | Bioorg Med Chem. 2010 Jan 15;18(2):822-9. Epub 2009 Nov 27.Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. | ||||
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