Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T77764 | ||||
Target Name | mRNA of Aurora B | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | 6-bromoindirubin-3-oxime | Drug Info | IC50 = 900 nM | [528968] | |
4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | Drug Info | IC50 = 782 nM | [530806] | ||
7-fluoroindirubin-3-acetoxime | Drug Info | IC50 = 8000 nM | [528968] | ||
Indirubin-3-methoxime | Drug Info | IC50 = 3000 nM | [528968] | ||
CGP-57380 | Drug Info | IC50 = 2500 nM | [529039] | ||
7-iodoindirubin-3-oxime | Drug Info | IC50 = 10000 nM | [528968] | ||
Indirubin-3-acetoxime | Drug Info | IC50 = 2100 nM | [528968] | ||
Indirubin-3-oxime | Drug Info | IC50 = 2300 nM | [528968] | ||
7-bromoindirubin-3-oxime | Drug Info | IC50 = 4600 nM | [528968] | ||
SU 6656 | Drug Info | IC50 = 19 nM | [529039] | ||
4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline | Drug Info | IC50 = 1250 nM | [529213] | ||
AZD-1152-HQPA | Drug Info | IC50 = 17 nM | [530037] | ||
HESPERADIN | Drug Info | IC50 = 250 nM | [528000] | ||
PHA-739358 | Drug Info | IC50 = 135 nM | [527513] | ||
7-fluoroindirubin-3-oxime | Drug Info | IC50 = 7000 nM | [528968] | ||
7-chloroindirubin-3-oxime | Drug Info | IC50 = 8000 nM | [528968] | ||
References | |||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 530806 | Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. Epub 2010 Mar 1.Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 529039 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 529039 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. | ||||
Ref 529213 | Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | ||||
Ref 530037 | J Med Chem. 2009 May 14;52(9):2629-51.Discovery and development of aurora kinase inhibitors as anticancer agents. | ||||
Ref 528000 | J Med Chem. 2006 Feb 9;49(3):955-70.Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. | ||||
Ref 527513 | J Med Chem. 2005 Apr 21;48(8):3080-4.Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
Ref 528968 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. |
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