| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T36056 | ||||
| Target Name | Geranylgeranyl transferase type I beta subunit | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | L-778123 | Drug Info | IC50 = 98 nM | [526941] | |
| L-745631 | Drug Info | IC50 = 10000 nM | [534466] | ||
| A-313326 | Drug Info | IC50 = 18 nM | [527321] | ||
| PD-83176 | Drug Info | IC50 = 1250 nM | [534307] | ||
| References | |||||
| Ref 526941 | Bioorg Med Chem Lett. 2004 Feb 9;14(3):639-43.Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I. | ||||
| Ref 534466 | J Med Chem. 1997 Sep 12;40(19):2971-90.Ras farnesyltransferase: a new therapeutic target. | ||||
| Ref 527321 | Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. | ||||
| Ref 534307 | J Med Chem. 1997 Jan 17;40(2):192-200.Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. | ||||
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