Target Validation Information
Target ID T15571
Target Name 5-hydroxytryptamine 5A receptor
Target Type
Research
Drug Potency against Target 5,6-dichloro-3,4-dihydroquinazolin-2-amine Drug Info Ki = 43 nM [529148]
4-propyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 805 nM [529148]
8-chloro-3,4-dihydroquinazolin-2-amine Drug Info Ki = 892 nM [529148]
METHIOTHEPIN Drug Info Ki = 1 nM [526655]
4-ethyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 24 nM [529148]
3,4-dihydroquinazolin-2-amine hydrobromide Drug Info Ki = 658 nM [529148]
(R)-zacopride Drug Info Ki = 16000 nM [526655]
5-chloro-3,4-dihydroquinazolin-2-amine Drug Info Ki = 99 nM [529148]
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 5.1 nM [529148]
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 84.4 nM [529148]
N,4-dimethyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 103 nM [529158]
N-butyl-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 189 nM [529158]
4-methyl-N-propyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 153 nM [529158]
(+/-)-nantenine Drug Info Ki = 2224 nM [530558]
8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 6.3 nM [529148]
SEROTONIN Drug Info IC50 = 184 nM [529569]
N,N-dimethyl-3,4-dihydroquinazolin-2-amine Drug Info Ki = 2800 nM [529148]
References
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 526655J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 526655J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529158Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
Ref 529158Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
Ref 529158Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
Ref 530558Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. Epub 2009 Nov 20.Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529569J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.