| Drug General Information |
| Drug ID |
D03ZHB
|
| Former ID |
DNC008151
|
| Drug Name |
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H12ClN3
|
| Canonical SMILES |
CCC1C2=C(C=CC=C2Cl)NC(=N1)N
|
| InChI |
1S/C10H12ClN3/c1-2-7-9-6(11)4-3-5-8(9)14-10(12)13-7/h3-5,7H,2H2,1H3,(H3,12,13,14)
|
| InChIKey |
MICIQKQOEFSTDP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 5A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 7 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
|
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Neuroactive ligand-receptor interaction
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Gap junction
|
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
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Serotonergic synapsehsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04014:Ras signaling pathway
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PANTHER Pathway
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5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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PathWhiz Pathway
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Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
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Reactome
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Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (s) signalling events
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WikiPathways
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
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GPCR downstream signaling
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GPCRs, Other
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| References |
| REF 1 | Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. |
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