Target Validation Information
Target ID T35527
Target Name Arachidonate 12-lipoxygenase, 12S-type
Target Type
Discontinued
Drug Potency against Target Polybrominated diphenyl ether derivative Drug Info IC50 = 2300 nM [527145]
DYSIDENIN Drug Info Ki = 9000 nM [529029]
NEODYSIDENIN Drug Info Ki = 17000 nM [529029]
(-)-7-N-methyldibromophakellin Drug Info IC50 = 10700 nM [527187]
PUUPEHENONE Drug Info IC50 = 2400 nM [526556]
Dimethylnordihydroguarierate acid Drug Info IC50 = 3100 nM [526556]
(+)-(5S,8S,10S)-20-methoxypuupehenol Drug Info IC50 = 280 nM [526556]
CHLOROPUUPEHENONE Drug Info IC50 = 2400 nM [526556]
Jaspic acid Drug Info IC50 = 7600 nM [526556]
2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol Drug Info IC50 = 700 nM [527145]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol Drug Info IC50 = 780 nM [526556]
(+)-(5S,8S,9R,10S)-20-methoxypuupehenone Drug Info IC50 = 260 nM [526556]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol Drug Info IC50 = 6000 nM [527145]
Isojaspic acid Drug Info IC50 = 3100 nM [530468]
PUUPEHEDIONE Drug Info IC50 = 18000 nM [530468]
References
Ref 527145J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Ref 529029Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Ref 529029Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Ref 527187J Nat Prod. 2004 Aug;67(8):1256-61.An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 527145J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 527145J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Ref 530468J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
Ref 530468J Nat Prod. 2009 Oct;72(10):1857-63.Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.

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