Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T89529 | ||||
Target Name | mRNA of Protein tyrosine phosphatase-1B | ||||
Target Type | Successful |
||||
Drug Potency against Target | USNIC ACID | Drug Info | IC50 = 16400 nM | [529326] | |
16-alphaH,17-isovaleryloxy-ent-kauran-19-oic acid | Drug Info | IC50 = 7100 nM | [528088] | ||
EVANS BLUE | Drug Info | IC50 = 1300 nM | [527017] | ||
TRYPAN BLUE | Drug Info | IC50 = 3900 nM | [527017] | ||
Abyssinone-VI-4-O-methyl ether | Drug Info | IC50 = 14800 nM | [528537] | ||
DYSIDINE | Drug Info | IC50 = 6700 nM | [529869] | ||
Ohioensin G | Drug Info | IC50 = 5600 nM | [529192] | ||
Mulberrofuran W | Drug Info | IC50 = 2700 nM | [530464] | ||
PHELLIGRIDIN I | Drug Info | IC50 = 3000 nM | [528656] | ||
Abyssinone-IV | Drug Info | IC50 = 16000 nM | [528537] | ||
Abyssinoflavanone VI | Drug Info | IC50 = 18900 nM | [528828] | ||
USIMINE A | Drug Info | IC50 = 15000 nM | [529326] | ||
BURTTINONE | Drug Info | IC50 = 18900 nM | [529806] | ||
CAULERPIN | Drug Info | IC50 = 3770 nM | [528096] | ||
FORMYLCHROMONE | Drug Info | Ki = 4300 nM | [531033] | ||
Oxalylaminobenzoic acid | Drug Info | Ki = 18 nM | [531033] | ||
OLEANOLIC_ACID | Drug Info | IC50 = 4200 nM | [530332] | ||
Isoxazolecarboxylic acid | Drug Info | Ki = 5700 nM | [531033] | ||
Oleanonic acid | Drug Info | IC50 = 3500 nM | [529697] | ||
ALBAFURAN A | Drug Info | IC50 = 9200 nM | [530464] | ||
URSOLIC ACID | Drug Info | IC50 = 3600 nM | [530454] | ||
NEORAUTENOL | Drug Info | IC50 = 7600 nM | [530454] | ||
Abyssinin II | Drug Info | IC50 = 17300 nM | [528828] | ||
Sigmoidin F | Drug Info | IC50 = 14200 nM | [528828] | ||
Kuwanon L | Drug Info | IC50 = 16900 nM | [527927] | ||
LICOAGROCHALCONE A | Drug Info | IC50 = 16900 nM | [528828] | ||
Ohioensin F | Drug Info | Ki = 1500 nM | [529192] | ||
24-hydroxyursolic acid | Drug Info | IC50 = 12800 nM | [529697] | ||
Erysubin E | Drug Info | IC50 = 8800 nM | [530454] | ||
Erybreadin D | Drug Info | IC50 = 6400 nM | [530454] | ||
3,9-Dihydroxy-4-prenyl-[6aR,11aR]pterocarpan | Drug Info | IC50 = 19500 nM | [530454] | ||
Isochroman mono-carboxylic acid | Drug Info | IC50 = 51.63 nM | [531033] | ||
Kuwanon R | Drug Info | IC50 = 8200 nM | [530464] | ||
Spathodic acid | Drug Info | IC50 = 18800 nM | [529697] | ||
Kuwanon V | Drug Info | IC50 = 13800 nM | [530464] | ||
5-deoxyabyssinin II | Drug Info | IC50 = 19200 nM | [528828] | ||
Abyssinoflavanone VII | Drug Info | IC50 = 15700 nM | [528828] | ||
SIGMOIDIN A | Drug Info | IC50 = 14400 nM | [528828] | ||
3alpha,24-dihydroxyolean-12-en-27-oic acid | Drug Info | IC50 = 11700 nM | [528115] | ||
3beta-acetoxyolean-12-en-27-oic acid | Drug Info | IC50 = 8500 nM | [528115] | ||
3beta-hydroxyurs-12-en-27-oic acid | Drug Info | IC50 = 4900 nM | [528115] | ||
3beta,6beta-dihydroxyolean-12-en-27-oic acid | Drug Info | IC50 = 12800 nM | [528115] | ||
3-oxoolean-12-en-27-oic acid | Drug Info | IC50 = 6800 nM | [528115] | ||
18beta-Glycyrrhetic acid | Drug Info | IC50 = 13800 nM | [528115] | ||
Methyl3beta-hydroxyolean-12-en-27-oate | Drug Info | IC50 = 16000 nM | [528115] | ||
ERYTHRIBYSSIN A | Drug Info | IC50 = 19300 nM | [530454] | ||
Pomolic acid | Drug Info | IC50 = 3900 nM | [529697] | ||
SIGMOIDIN B | Drug Info | IC50 = 19400 nM | [528828] | ||
Augustic acid | Drug Info | IC50 = 4930 nM | [530467] | ||
3-epi-masilinic acid | Drug Info | IC50 = 14330 nM | [530467] | ||
Sanggenon C | Drug Info | IC50 = 2600 nM | [527927] | ||
OHIOENSIN A | Drug Info | IC50 = 4300 nM | [529192] | ||
ERTIPROTAFIB | Drug Info | IC50 = 1400 nM | [529004] | ||
3beta-hydroxyolean-12-en-27-oic acid | Drug Info | IC50 = 5200 nM | [528115] | ||
18alpha-Glycyrrhetic acid | Drug Info | IC50 = 15600 nM | [528115] | ||
Mulberrofuran D | Drug Info | IC50 = 4300 nM | [530464] | ||
Ohioensin C | Drug Info | IC50 = 7600 nM | [529192] | ||
1,2,3,4,6-penta-O-galloyl-D-glucopyranose | Drug Info | IC50 = 4800 nM | [531140] | ||
RK-682 | Drug Info | IC50 = 4400 nM | [531115] | ||
3-(4,5-Bis-biphenyl-4-yl-1H-imidazol-2-yl)-phenol | Drug Info | IC50 = 8600 nM | [526334] | ||
Kuwanon J | Drug Info | IC50 = 2700 nM | [530464] | ||
Methyl 3beta-hydroxyolean-12-en-28-oate | Drug Info | IC50 = 14200 nM | [528115] | ||
Rotungenic acid | Drug Info | IC50 = 10900 nM | [529697] | ||
Abyssinin I | Drug Info | IC50 = 18200 nM | [528828] | ||
4'-((2-butylbenzofuran-3-yl)methyl)biphenyl-4-ol | Drug Info | IC50 = 1190 nM | [530028] | ||
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione | Drug Info | IC50 = 19590 nM | [527986] | ||
1,2-NAPHTHOQUINONE | Drug Info | IC50 = 1640 nM | [526377] | ||
LICOAGROCHACONE A | Drug Info | IC50 = 19100 nM | [530275] | ||
Sanggenon G | Drug Info | IC50 = 1600 nM | [527927] | ||
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione | Drug Info | IC50 = 13660 nM | [527986] | ||
MASLINIC ACID | Drug Info | IC50 = 5930 nM | [530467] | ||
4'-(2-butylbenzofuran-3-yl)biphenyl-4-ol | Drug Info | IC50 = 740 nM | [530028] | ||
Mulberrofuran C | Drug Info | IC50 = 4900 nM | [527927] | ||
ERYBREADIN B | Drug Info | IC50 = 4200 nM | [530454] | ||
UVAOL | Drug Info | IC50 = 15600 nM | [529697] | ||
19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid | Drug Info | IC50 = 8100 nM | [529697] | ||
CHROMOTROPATE | Drug Info | IC50 = 9700 nM | [527017] | ||
FOLITENOL | Drug Info | IC50 = 7800 nM | [530454] | ||
Erybreadin C | Drug Info | IC50 = 7300 nM | [530454] | ||
Action against Disease Model | ISIS 113715 | In cultured monkey hepatocytes, ISIS 113715 treatment dose-dependently reduced PTP-1B mRNA expression, with an IC 50 of less than 10 nM. | [552912] | Drug Info | |
The Effect of Target Knockout, Knockdown or Genetic Variations | Although heterozygous loss of PTP1B has no effect on t uMorigenesis,homozygous PTP1B deficiency dramatically delays or prevents the onset of MMTV-NeuNT-evoked breast t uMors. The effects of PTP1B deficiency correlate with defective extracellular signal-regulated kinase activation in preneoplastic mammary glands from compound mutant mice.In contrast,PTP1B deficiency has no effect on MMTV-polyoma middle T t uMorigenesis. Our data raise the possibility that PTP1B inhibitors may be chemopreventative for some forms of breast cancer. | [552912] | |||
References | |||||
Ref 529326 | J Nat Prod. 2008 Apr;71(4):710-2. Epub 2008 Feb 21.Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum. | ||||
Ref 528088 | Bioorg Med Chem Lett. 2006 Jun 1;16(11):3061-4. Epub 2006 Mar 20.Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum. | ||||
Ref 527017 | Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. | ||||
Ref 527017 | Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. | ||||
Ref 528537 | J Nat Prod. 2006 Nov;69(11):1572-6.Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii. | ||||
Ref 529869 | Bioorg Med Chem Lett. 2009 Jan 15;19(2):390-2. Epub 2008 Nov 24.A novel sesquiterpene quinone from Hainan sponge Dysidea villosa. | ||||
Ref 529192 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. Epub 2007 Nov 17.Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. | ||||
Ref 530464 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. Epub 2009 Oct 7.Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | ||||
Ref 528656 | J Nat Prod. 2007 Feb;70(2):296-9. Epub 2007 Feb 6.Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius. | ||||
Ref 528537 | J Nat Prod. 2006 Nov;69(11):1572-6.Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 529326 | J Nat Prod. 2008 Apr;71(4):710-2. Epub 2008 Feb 21.Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum. | ||||
Ref 529806 | Bioorg Med Chem. 2008 Dec 15;16(24):10356-62. Epub 2008 Oct 10.Flavanones from the stem bark of Erythrina abyssinica. | ||||
Ref 528096 | Bioorg Med Chem Lett. 2006 Jun 1;16(11):2947-50. Epub 2006 Mar 24.Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. | ||||
Ref 531033 | Eur J Med Chem. 2010 Sep;45(9):3709-18. Epub 2010 May 15.Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. | ||||
Ref 531033 | Eur J Med Chem. 2010 Sep;45(9):3709-18. Epub 2010 May 15.Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. | ||||
Ref 530332 | J Nat Prod. 2009 Sep;72(9):1620-6.Chemical Constituents of the Roots of Euphorbia micractina. | ||||
Ref 531033 | Eur J Med Chem. 2010 Sep;45(9):3709-18. Epub 2010 May 15.Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 530464 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. Epub 2009 Oct 7.Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 527927 | Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. Epub 2005 Dec 13.Protein tyrosine phosphatase 1B inhibitors from Morus root bark. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 529192 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. Epub 2007 Nov 17.Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 531033 | Eur J Med Chem. 2010 Sep;45(9):3709-18. Epub 2010 May 15.Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. | ||||
Ref 530464 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. Epub 2009 Oct 7.Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 530464 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. Epub 2009 Oct 7.Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 530467 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. Epub 2009 Oct 8.Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. | ||||
Ref 530467 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. Epub 2009 Oct 8.Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. | ||||
Ref 527927 | Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. Epub 2005 Dec 13.Protein tyrosine phosphatase 1B inhibitors from Morus root bark. | ||||
Ref 529192 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. Epub 2007 Nov 17.Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. | ||||
Ref 529004 | Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60. Epub 2007 Aug 15.2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 530464 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. Epub 2009 Oct 7.Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | ||||
Ref 529192 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. Epub 2007 Nov 17.Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. | ||||
Ref 531140 | J Nat Prod. 2010 Sep 24;73(9):1578-81.Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. | ||||
Ref 531115 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401. Epub 2010 Aug 1.Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. | ||||
Ref 526334 | J Med Chem. 2002 May 23;45(11):2213-21.Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. | ||||
Ref 530464 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. Epub 2009 Oct 7.Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. | ||||
Ref 528115 | Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. Epub 2006 Mar 31.Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. | ||||
Ref 552912 | Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys. Endocrinology. 2009 Apr;150(4):1670-9. doi: 10.1210/en.2008-0885. Epub 2009 Jan 22. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 528828 | J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. | ||||
Ref 530028 | Bioorg Med Chem. 2009 Apr 1;17(7):2658-72. Epub 2009 Mar 5.Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors. | ||||
Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
Ref 526377 | Bioorg Med Chem Lett. 2002 Aug 5;12(15):1941-6.Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents. | ||||
Ref 530275 | Bioorg Med Chem Lett. 2009 Sep 1;19(17):5155-7. Epub 2009 Jul 24.Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. | ||||
Ref 527927 | Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. Epub 2005 Dec 13.Protein tyrosine phosphatase 1B inhibitors from Morus root bark. | ||||
Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
Ref 530467 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. Epub 2009 Oct 8.Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. | ||||
Ref 530028 | Bioorg Med Chem. 2009 Apr 1;17(7):2658-72. Epub 2009 Mar 5.Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors. | ||||
Ref 527927 | Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. Epub 2005 Dec 13.Protein tyrosine phosphatase 1B inhibitors from Morus root bark. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 529697 | J Nat Prod. 2008 Oct;71(10):1775-8. Epub 2008 Sep 18.Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. | ||||
Ref 527017 | Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.