Drug Information

Drug General Information
Drug ID
D0U9HN
Former ID
DNC008531
Drug Name
DYSIDINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529869]
Structure
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2D MOL

3D MOL
Formula
C23H33NO6S
Canonical SMILES
CC1C2CCC=C(C2(CCC1(C)CC3=C(C(=CC(=O)C3=O)NCCS(=O)(=O)O)<br />O)C)C
InChI
1S/C23H33NO6S/c1-14-6-5-7-17-15(2)22(3,8-9-23(14,17)4)13-16-20(26)18(12-19(25)21(16)27)24-10-11-31(28,29)30/h6,12,15,17,24,26H,5,7-11,13H2,1-4H3,(H,28,29,30)/t15-,17+,22-,23-/m1/s1
InChIKey
JUZCKAMLAZUOHD-CIVZFWGOSA-N
PubChem Compound ID
10321583
Target and Pathway
Target(s) mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [529869]
Phospholipase A2, membrane associated Target Info Inhibitor [526069]
BioCyc Pathway Phospholipases
KEGG Pathway Adherens junction
Insulin signaling pathwayhsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
Pathway Interaction Database Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling eventsglypican_1pathway:Glypican 1 network
Reactome Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signalingR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signalingWP2795:Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Spinal Cord Injury
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 529869Bioorg Med Chem Lett. 2009 Jan 15;19(2):390-2. Epub 2008 Nov 24.A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.
Ref 526069J Nat Prod. 2001 May;64(5):612-5.New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.
Ref 529869Bioorg Med Chem Lett. 2009 Jan 15;19(2):390-2. Epub 2008 Nov 24.A novel sesquiterpene quinone from Hainan sponge Dysidea villosa.

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