Target Validation Information
Target ID T30082
Target Name Acetylcholinesterase
Target Type
Successful
Drug Potency against Target LYSICAMINE Drug Info IC50 = 16100 nM
Pyridostigmine Drug Info IC50 = 330 nM [553077]
5-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info IC50 = 36 nM
Neostigmine Drug Info IC50 = 36 nM [553191]
8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info IC50 = 4.43 nM
(-)-Phenserine Drug Info IC50 = 24 nM
(3R)-9-amino-3-methyl-1,2,3,4-tetrahydroacridine Drug Info IC50 = 1384 nM [530551]
3-(2-N-Pyrrolyl-acetamino)-rutaecarpine Drug Info IC50 = 131.2 nM [530639]
N-n-nonyl-7-methoxytacrine hydrochloride Drug Info IC50 = 1600 nM [531150]
N-n-octyl-7-methoxytacrine hydrochloride Drug Info IC50 = 360 nM [531150]
N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP Drug Info IC50 = 42 nM [529368]
N-n-pentyl-7-methoxytacrine hydrochloride Drug Info IC50 = 6700 nM [531150]
6-hydroxy-2-methyl-9H-beta-carbolin-2-ium Drug Info IC50 = 4200 nM [528415]
3-(2-N-Piperidyl-acetamino)-rutaecarpine Drug Info IC50 = 111.4 nM [530639]
Iso-OMPA Drug Info IC50 = 2500 nM [529716]
N-Methyl-1'H-phenothiazine-1'-carboxamide Drug Info Ki = 9360 nM [530749]
6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 1000 nM [528415]
24-ethyl-cholest-7-ene-3,5,6-triol Drug Info Ki = 12600 nM [527846]
9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide Drug Info IC50 = 340 nM [530920]
3-[4-(benzylmethylamino)butoxy]xanthen-9-one Drug Info IC50 = 6250 nM [528456]
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one Drug Info IC50 = 2890 nM [528456]
3-[3-(benzylmethylamino)propoxy]xanthen-9-one Drug Info IC50 = 2680 nM [528456]
4-[4-(benzhydryloxy)piperidino]butyl benzoate Drug Info IC50 = 1310 nM [528979]
9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide Drug Info IC50 = 224 nM [530625]
9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide Drug Info IC50 = 123 nM [530625]
6-methoxy-2-methyl-9H-beta-carbolin-2-ium Drug Info IC50 = 2200 nM [528415]
2-morpholino-N-phenethylpyrimidin-4-amine Drug Info IC50 = 4800 nM [530923]
9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide Drug Info IC50 = 398 nM [530625]
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one Drug Info IC50 = 7780 nM [528456]
Isoflurophate Drug Info IC50 = 640 nM [553171]
MESUAGENIN B Drug Info IC50 = 700 nM [531213]
4-ISOPROPYLPHENSERINE Drug Info IC50 = 8400 nM [530692]
2-Hex-5-enyl-5-nonyl-pyrrolidine Drug Info Ki = 1500 nM
GANSTIGMINE Drug Info IC50 = 5120 nM [529473]
LIPOCRINE Drug Info IC50 = 0.253 nM [530437]
4-formylphenyl-O-beta-Dglucopyranoside Drug Info Ki = 730 nM [528897]
9-amino-7H-dibenzo[de,h]quinolin-7-one Drug Info Ki = 3860 nM [529985]
7-Oxo-7H-dibenzo[de,g]quinoline Drug Info Ki = 14580 nM [529985]
But-3-enyl-trimethyl-ammonium bromide Drug Info IC50 = 8.48 nM [534296]
4-formylphenyl-O-beta-D-ribopyranoside Drug Info Ki = 510 nM [528897]
HALOXYSTEROL B Drug Info Ki = 850 nM [527846]
9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide Drug Info IC50 = 520 nM [530625]
CORONARIDINE Drug Info IC50 = 8600 nM [531166]
TASPINE Drug Info IC50 = 330 nM [528444]
2-Propyl-beta-carboline-2-ium iodide Drug Info IC50 = 845 nM [530824]
2-Hex-5-enyl-5-non-8-enyl-3,4-dihydro-2H-pyrrole Drug Info Ki = 13000 nM
9-Amino-1,2,3,4-tetrahydro-acridine-1,7-diol Drug Info IC50 = 10600 nM
6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info Ki = 1 nM [526093]
LAWSARITOL Drug Info Ki = 16100 nM [527846]
CHLORANIL Drug Info Ki = 163 nM [527510]
N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine Drug Info IC50 = 12000 nM [530923]
HALOXYSTEROL A Drug Info Ki = 7600 nM [527846]
Huprine X Drug Info Ki = 0.13 nM [529473]
Isosorbide-di-(ethylcarbamate) Drug Info IC50 = 6500 nM [530646]
1,9-bis(pyridinium)-nonane dibromide Drug Info IC50 = 2000 nM [530696]
N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP Drug Info IC50 = 24 nM [529368]
4ALPHA-(HYDROXYMETHYL)-4ALPHA-DEMETHYLTERRITREM B Drug Info IC50 = 0.423 nM [534457]
N-propylnorlitebamine Drug Info IC50 = 7210 nM [534555]
N-benzyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine Drug Info IC50 = 9800 nM [530923]
BIS(20)-HUPERZINE B Drug Info IC50 = 25.2 nM [527419]
CLEBOPRIDE Drug Info IC50 = 890 nM [527214]
CAPROCTAMINE Drug Info IC50 = 170 nM [529775]
Tacrine Drug Info IC50 = 200 nM [553077]
N-ALLYLNORGALANTHAMINE Drug Info IC50 = 180 nM [529384]
(+/-)-huprineY hydrochloride Drug Info IC50 = 0.78 nM [528570]
Carinatumins B (2) Drug Info IC50 = 7000 nM [528591]
9-hydrazino-1,2,3,4-tetrahydroacridine Drug Info IC50 = 13000 nM [528564]
VELNACRINE Drug Info IC50 = 1300 nM
DECIDIUM Drug Info Ki = 21.3 nM [529473]
Chlorphrifos oxon Drug Info IC50 = 63 nM [529440]
3-hydroxy-N,N,N-trimethylbenzenaminium iodide Drug Info IC50 = 12000 nM [529567]
Isopropyl dodecylfluorophosphonate Drug Info IC50 = 6300 nM [529440]
TURBINATINE Drug Info IC50 = 1860 nM [527312]
CHF-2819 Drug Info IC50 = 5120 nM [528371]
GENESERINE Drug Info IC50 = 1740 nM [528371]
AP-2238 Drug Info IC50 = 44 nM [530741]
Pseudopalmatine trifluoroacetate Drug Info IC50 = 1800 nM
6-Methyl-4-(4-benzoylpiperazin-1-yl)coumarin Drug Info IC50 = 7400 nM [529641]
PARAOXON Drug Info IC50 = 13 nM [529440]
Malathion Drug Info IC50 = 2500 nM [552687]
Petrosamine Drug Info IC50 = 91 nM [529521]
BENZOQUINONE Drug Info Ki = 955 nM [527510]
7-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine Drug Info IC50 = 40 nM
Isosorbide-2-(methylcarbamate)-5-mononitrate Drug Info IC50 = 17200 nM [529716]
INFRACTOPICRIN Drug Info IC50 = 9720 nM [530743]
10-Hydroxy-infractopicrin Drug Info IC50 = 12700 nM [530743]
3-(2-N-Piperidyl-propionamino)-rutaecarpine Drug Info IC50 = 21.4 nM [530639]
1,3-Bis-(3-imidazolidin-2-yl-phenyl)-urea Drug Info IC50 = 590 nM [527214]
Huprine Y Drug Info IC50 = 1.84 nM [530171]
Mesuagenin D Drug Info IC50 = 8730 nM [531213]
(RS)-tacrine(10)-hupyridone Drug Info IC50 = 8.8 nM [529473]
MEMOQUIN Drug Info IC50 = 1.5 nM [530437]
(-)-huperzine B Drug Info Ki = 334 nM [529473]
5-Hex-5-enyl-2-nonyl-3,4-dihydro-2H-pyrrole Drug Info Ki = 5000 nM
1,10-bis(pyridinium)-decane dibromide Drug Info IC50 = 400 nM [530696]
Galanthamine derivative Drug Info IC50 = 4 nM [529473]
(24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol Drug Info IC50 = 19200 nM [527846]
Haloxysterol D Drug Info Ki = 17000 nM [527846]
(4-Iodo-butyl)-trimethyl-ammonium iodide Drug Info IC50 = 4.71 nM [534296]
QUILOSTIGMINE Drug Info IC50 = 148 nM [531080]
Ethyl octylfluorophosphonate Drug Info IC50 = 120 nM [529440]
BIS(12)-HUPERZINE B Drug Info IC50 = 76.2 nM [527419]
BIS(9)-HUPERZINE B Drug Info IC50 = 471 nM [527419]
BIS(16)-HUPERZINE B Drug Info IC50 = 18.5 nM [527419]
BIS(18)-HUPERZINE B Drug Info IC50 = 4.93 nM [527419]
N-isobutylnorlitebamine Drug Info IC50 = 6510 nM [534555]
N-benzylnorlitebamine Drug Info IC50 = 10670 nM [534555]
N-isopropylnorlitebamineN-methoiodide Drug Info IC50 = 2790 nM [534555]
(S,S)-(-)-bis(12)-hupyridone Drug Info Ki = 19.6 nM [529473]
N-allylnorlitebamine Drug Info IC50 = 15800 nM [534555]
(S,S)-(-)-bis(10)-hupyridone Drug Info Ki = 0.8 nM [529473]
VOACANGINE Drug Info IC50 = 4400 nM [531166]
(4-Bromo-butyl)-trimethyl-ammonium Drug Info IC50 = 5.97 nM [534296]
Dimethyl-pent-4-enyl-ammonium bromide Drug Info IC50 = 1.13 nM [534296]
1,11-bis(pyridinium)-undecane dibromide Drug Info Ki = 30 nM [530696]
Trimethyl-(4-oxo-pentyl)-ammonium iodide Drug Info IC50 = 8.48 nM [534296]
CHOLINE IODIDE Drug Info IC50 = 3.01 nM [534296]
N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP Drug Info IC50 = 1000 nM [529368]
N-benzyl-2-thiomorpholinopyrimidin-4-amine Drug Info IC50 = 330 nM [530923]
N,N'-(1',6-hexylene)-bis-(-)-nor-MEP Drug Info IC50 = 1220 nM [529368]
3-(2-N-Pyrrolyl-propionamino)-rutaecarpine Drug Info IC50 = 29.24 nM [530639]
3-(2-Diethylamino-acetamino)-rutaecarpine Drug Info IC50 = 372.3 nM [530639]
9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide Drug Info IC50 = 490 nM [530920]
N-n-heptyl-7-methoxytacrine hydrochloride Drug Info IC50 = 270 nM [531150]
N-n-dodecyl-7-methoxytacrine hydrochloride Drug Info IC50 = 1000 nM [531150]
9-O-[3-(Phenylamino)propyl]-berberine bromide Drug Info IC50 = 138 nM [530920]
N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP Drug Info IC50 = 3.9 nM [529368]
7-methoxytacrine Drug Info IC50 = 15000 nM [531150]
N,N'-(1',8'-octylene)-bis-(-)-nor-MEP Drug Info IC50 = 79 nM [529368]
6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 1900 nM [528415]
(2-Chloro-ethyl)-trimethyl-ammonium chloride Drug Info IC50 = 2.39 nM [534296]
N-n-propyl-7-methoxytacrine hydrochloride Drug Info IC50 = 9200 nM [531150]
6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole Drug Info IC50 = 11800 nM [528415]
Trimethyl-(3-nitro-phenyl)-ammonium iodide Drug Info IC50 = 6.28 nM [534296]
6-Methyl-4-(4-o-tolylpiperazin-1-yl)coumarin Drug Info IC50 = 7900 nM [529641]
3-(2-Diethylamino-propionamino)-rutaecarpine Drug Info IC50 = 80.2 nM [530639]
N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP Drug Info IC50 = 270 nM [529368]
N,N'-(1',10'-decylene)-bis-(-)-nor-MEP Drug Info IC50 = 9.5 nM [529368]
3-(3-Carboxy-propionylamino)-benzoic acid Drug Info IC50 = 92.5 nM [526619]
(3-Hydroxy-2-methyl-phenyl)-trimethyl-ammonium Drug Info IC50 = 1.92 nM [534296]
Hexyl-trimethyl-ammonium Drug Info IC50 = 8.16 nM [534296]
3-(4-Phenylpiperazin-1-carbonyl)coumarin Drug Info IC50 = 9300 nM [529641]
(2-Butyryloxy-ethyl)-trimethyl-ammonium iodide Drug Info IC50 = 2.29 nM [534296]
Allyl-trimethyl-ammonium Drug Info IC50 = 2.92 nM [534296]
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one Drug Info IC50 = 2820 nM [528456]
3-(4-o-Tolylpiperazine-1-carbonyl)coumarin Drug Info IC50 = 6700 nM [529641]
(5-Bromo-pentyl)-trimethyl-ammonium Drug Info IC50 = 5.34 nM [534296]
1,4-Di(berberine-9-O-yl)ethane dibromide Drug Info IC50 = 176 nM [530920]
(2-Ethoxy-ethyl)-trimethyl-ammonium iodide Drug Info IC50 = 1.16 nM [534296]
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 800 nM [528415]
N-benzyl-2-morpholinopyrimidin-4-amine Drug Info IC50 = 500 nM [530923]
24-ethylcholest-6-ene-3,5-diol Drug Info Ki = 4000 nM [527846]
(3-Bromo-propyl)-trimethyl-ammonium Drug Info IC50 = 8.79 nM [534296]
9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide Drug Info Ki = 45 nM [530625]
6-methoxy-2,9-dimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 1300 nM [528415]
1,3-Di(berberine-9-O-yl)ethane dibromide Drug Info IC50 = 226 nM [530920]
THIOCTIC ACID Drug Info IC50 = 1 nM [529250]
Galantamine Drug Info IC50 = 365 nM [552492]
(-)-Tolserine Drug Info IC50 = 10.3 nM
AP-2243 Drug Info IC50 = 18 nM [529149]
Isosorbide-di-(4-nitrophenyl carbamate) Drug Info IC50 = 5400 nM [530646]
1,2-Di(berberine-9-O-yl)ethane dibromide Drug Info IC50 = 320 nM [530920]
6-Methyl-4-(4-phenylpiperazin-1-yl)coumarin Drug Info IC50 = 4500 nM [529641]
XANTHOSTIGMINE Drug Info IC50 = 20 nM [534716]
9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide Drug Info IC50 = 743 nM [530920]
CRYPTADINE B Drug Info IC50 = 18500 nM [529072]
Alkylene Linked Bis-Galanthamine derivative Drug Info IC50 = 230 nM [525746]
(2-Mercapto-ethyl)-trimethyl-ammonium iodide Drug Info IC50 = 4.4 nM [534296]
ETHYLPHENSERINE Drug Info IC50 = 10 nM [531080]
Ambenonium Drug Info IC50 = 0.698 nM [552374]
Edrophonium Drug Info IC50 = 5220 nM [552256]
1,2-NAPHTHOQUINONE Drug Info Ki = 320 nM [529103]
NSC-23180 Drug Info Ki = 850 nM [529103]
3,4,5,6-Tetrachloro-[1,2]benzoquinone Drug Info Ki = 1670 nM [527510]
Cis-2,6-dimethyl-1-methyl sulfonyl piperidine Drug Info IC50 = 90 nM [530187]
1-benzene sulfonyl-cis-2,6-dimethyl piperidine Drug Info IC50 = 388 nM [530187]
5,6-dinitroacenaphthoquinone Drug Info Ki = 903 nM [529103]
3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1H-indazole Drug Info IC50 = 120 nM [527249]
Icopezil maleate Drug Info IC50 = 0.33 nM [527249]
9-Ethyl-2-methyl-beta-carboline-2-ium iodide Drug Info IC50 = 2567 nM [530824]
6-chlorotacrine hydrochloride Drug Info IC50 = 5.73 nM [530301]
Pseudocolumbamine trifluoroacetate Drug Info IC50 = 5000 nM
BIS(8)-HUPERZINE B Drug Info IC50 = 1020 nM [527419]
Haloxysterol C Drug Info Ki = 1100 nM [527846]
N-isopropylnorlitebamine Drug Info IC50 = 6800 nM [534555]
1-(3-Bromomethyl-phenyl)-2,2,2-trifluoro-ethanone Drug Info IC50 = 360 nM [526149]
Bis-7-tacrine Drug Info IC50 = 1.8 nM [530923]
3-(dimethylamino)phenyl phenylcarbamate Drug Info IC50 = 2500 nM
N-(14-methylallyl)norgalanthamine Drug Info IC50 = 160 nM [529384]
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one Drug Info IC50 = 10300 nM [528456]
HEPTYPHYSOSTIGMINE Drug Info IC50 = 22 nM [531080]
N-butylnorlitebamine Drug Info IC50 = 7790 nM [534555]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info Ki < 1000 nM [531079]
3-(2,5-Dioxo-pyrrolidin-1-yl)-benzoic acid Drug Info IC50 = 33.4 nM [526619]
3-(4-Benzoylpiperazine-1-carbonyl)coumarin Drug Info IC50 = 15000 nM [529641]
TOLSERINE Drug Info IC50 = 40 nM [531080]
6-hydroxy-2,9-dimethyl-9H-beta-carbolin-2-ium Drug Info IC50 = 1800 nM [528415]
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine Drug Info IC50 = 13200 nM [528402]
MESUAGENIN A Drug Info IC50 = 1060 nM [531213]
N-n-hexyl-7-methoxytacrine hydrochloride Drug Info IC50 = 100 nM [531150]
2-Hex-5-enyl-5-non-8-enyl-pyrrolidine Drug Info Ki = 2500 nM
References
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