Target Information
Target General Infomation | |||||
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Target ID |
T81015
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Former ID |
TTDR01089
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Target Name |
Orotidine 5'-phosphate decarboxylase
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Gene Name |
pyrF
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Synonyms |
OMP decarboxylase; OMPDCase; OMPdecase; pyrF
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Target Type |
Research
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BioChemical Class |
Carbon-carbon lyase
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Target Validation |
T81015
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UniProt ID | |||||
EC Number |
EC 4.1.1.23
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Sequence |
MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKP
QVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADA VTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGA ANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLL PAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV |
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References | |||||
Ref 528351 | J Med Chem. 2006 Aug 10;49(16):4937-45.Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. |
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