Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T79724
|
||||
| Former ID |
TTDR00748
|
||||
| Target Name |
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
|
||||
| Gene Name |
folK
|
||||
| Synonyms |
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; 7,8- dihydro-6-hydroxymethylpterin-pyrophosphokinase; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; PPPK; folK
|
||||
| Target Type |
Research
|
||||
| BioChemical Class |
Kinase
|
||||
| UniProt ID | |||||
| EC Number |
EC 2.7.6.3
|
||||
| Sequence |
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVA
LETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMK NRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW |
||||
| Inhibitor | 6-Hydroxymethyl-7,8-Dihydropterin | Drug Info | [1] | ||
| 6-Hydroxymethylpterin | Drug Info | [2] | |||
| Acetate Ion | Drug Info | [1] | |||
| Adenosine-5'-Diphosphate | Drug Info | [2] | |||
| Alpha,Beta-Methyleneadenosine-5'-Triphosphate | Drug Info | [1] | |||
| P(1)-(6-Hydroxymethylpterin)-P(2)-(5'-adenosyl)diphosphate | Drug Info | [3] | |||
| P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate | Drug Info | [3] | |||
| [Pterin-6-Yl Methanyl]-Phosphonophosphate | Drug Info | [1] | |||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
| REF 3 | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.